Structural and functional characterization of interactions involving the Tfb1 subunit of TFIIH and the NER factor Rad2

The general transcription factor IIH (TFIIH) plays crucial roles in transcription as part of the pre-initiation complex (PIC) and in DNA repair as part of the nucleotide excision repair (NER) machinery. During NER, TFIIH recruits the 3'-endonuclease Rad2 to damaged DNA. In this manuscript, we f...

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Veröffentlicht in:	Nucleic acids research 2012-07, Vol.40 (12), p.5739-5750
Hauptverfasser:	Lafrance-Vanasse, Julien, Arseneault, Geneviève, Cappadocia, Laurent, Chen, Hung-Ta, Legault, Pascale, Omichinski, James G
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Binding Sites DNA-Binding Proteins - chemistry DNA-Binding Proteins - metabolism Endodeoxyribonucleases - chemistry Endodeoxyribonucleases - metabolism Models, Molecular Molecular Sequence Data Nuclear Magnetic Resonance, Biomolecular Protein Structure, Tertiary Protein Subunits - chemistry Protein Subunits - genetics Protein Subunits - metabolism Radiation Tolerance Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - growth & development Saccharomyces cerevisiae - radiation effects Saccharomyces cerevisiae Proteins - chemistry Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Sequence Deletion Structural Biology Transcription Factors, TFII - chemistry Transcription Factors, TFII - genetics Transcription Factors, TFII - metabolism Tumor Suppressor Protein p53 - chemistry Ultraviolet Rays
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