Full-length axon regeneration in the adult mouse optic nerve and partial recovery of simple visual behaviors

The mature optic nerve cannot regenerate when injured, leaving victims of traumatic nerve damage or diseases such as glaucoma with irreversible visual losses. Recent studies have identified ways to stimulate retinal ganglion cells to regenerate axons part-way through the optic nerve, but it remains...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2012-06, Vol.109 (23), p.9149-9154
Hauptverfasser:	de Lima, Silmara, Koriyama, Yoshiki, Kurimoto, Takuji, Oliveira, Julia Teixeira, Yin, Yuqin, Li, Yiqing, Gilbert, Hui-Ya, Fagiolini, Michela, Martinez, Ana Maria Blanco, Benowitz, Larry
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal behavior Animals Axons Axons - physiology Biological Sciences Brain Calcium-Binding Proteins - secretion Cells Circadian Rhythm - physiology Cyclic AMP - metabolism Dependovirus Eyes Ganglia Gene Deletion Genetic Vectors - genetics Geniculate Bodies - physiology Innervation Integrases - metabolism Mice Nerves Neurons Neuroscience Optic nerve Optic Nerve - cytology Optic Nerve - physiology Optic nerve injuries Optic Nerve Injuries - drug therapy Optics PTEN Phosphohydrolase - genetics Regeneration - physiology Retina Retinal Ganglion Cells - cytology Retinal Ganglion Cells - physiology Rodents Superior Colliculi - physiology Zymosan - administration & dosage Zymosan - pharmacology
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