Loss of heterozygosity in 7q myeloid disorders: clinical associations and genomic pathogenesis

Loss of heterozygosity affecting chromosome 7q is common in acute myeloid leukemia and myelodysplastic syndromes, pointing toward the essential role of this region in disease phenotype and clonal evolution. The higher resolution offered by recently developed genomic platforms may be used to establis...

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Veröffentlicht in:	Blood 2012-06, Vol.119 (25), p.6109-6117
Hauptverfasser:	Jerez, Andres, Sugimoto, Yuka, Makishima, Hideki, Verma, Amit, Jankowska, Anna M., Przychodzen, Bartlomiej, Visconte, Valeria, Tiu, Ramon V., O'Keefe, Christine L., Mohamedali, Azim M., Kulasekararaj, Austin G., Pellagatti, Andrea, McGraw, Kathy, Muramatsu, Hideki, Moliterno, Alison R., Sekeres, Mikkael A., McDevitt, Michael A., Kojima, Seiji, List, Alan, Boultwood, Jacqueline, Mufti, Ghulam J., Maciejewski, Jaroslaw P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Biological and medical sciences Bone Marrow Diseases - epidemiology Bone Marrow Diseases - genetics Bone Marrow Diseases - pathology Chromosome Aberrations Chromosome Deletion Chromosomes, Human, Pair 7 - genetics Cohort Studies Female Genetic Association Studies Genome, Human Hematologic and hematopoietic diseases Humans Loss of Heterozygosity - genetics Male Medical sciences Middle Aged Myelodysplastic Syndromes - epidemiology Myelodysplastic Syndromes - genetics Myeloid Cells - metabolism Myeloid Cells - pathology Myeloid Neoplasia Polymorphism, Single Nucleotide
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