Antioxidant Dietary Supplementation in Mice Exposed to Proton Radiation Attenuates Expression of Programmed Cell Death-Associated Genes

Dietary antioxidants have radioprotective effects after ionizing radiation exposure that limit hematopoietic cell depletion. We sought to determine the mechanism of proton-induced hematopoietic cell death in animals receiving a moderate dose of whole-body proton radiation. In addition, animals were...

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Veröffentlicht in:	Radiation research 2011-05, Vol.175 (5), p.650-656
Hauptverfasser:	Sanzari, J. K., Wambi, C., Lewis-Wambi, J. S., Kennedy, A. R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants Antioxidants - pharmacology Apoptosis Apoptosis - drug effects Apoptosis - genetics Apoptosis - radiation effects bcl-X Protein - genetics bcl-X Protein - metabolism Bone marrow Bone marrow cells Bone Marrow Cells - cytology Bone Marrow Cells - drug effects Bone Marrow Cells - metabolism Bone Marrow Cells - radiation effects Cell Count Diet Dietary Supplements Gene Expression Regulation - drug effects Gene Expression Regulation - radiation effects Irradiation Male Messenger RNA Mice Mitochondria Proto-Oncogene Proteins c-bcl-2 - genetics Proto-Oncogene Proteins c-bcl-2 - metabolism Protons Protons - adverse effects Radiation dosage RNA, Messenger - genetics RNA, Messenger - metabolism Time Factors Transforming Growth Factor beta1 - genetics Up-Regulation - drug effects Up-Regulation - radiation effects Whole-Body Irradiation - adverse effects
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