Autonomous murine T-cell progenitor production in the extra-embryonic yolk sac before HSC emergence

The extra-embryonic yolk sac (YS) is the first hematopoietic site in the mouse embryo and is thought to generate only primitive erythroid and myeloerythroid progenitor cells before definitive HSC emergence within the embryo on E10.5. Here, we have shown the existence of T cell–restricted progenitors...

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Veröffentlicht in:	Blood 2012-06, Vol.119 (24), p.5706-5714
Hauptverfasser:	Yoshimoto, Momoko, Porayette, Prashanth, Glosson, Nicole L., Conway, Simon J., Carlesso, Nadia, Cardoso, Angelo A., Kaplan, Mark H., Yoder, Mervin C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Aorta - embryology Biological and medical sciences Cell Differentiation Endothelial Cells - cytology Endothelial Cells - metabolism Hematologic and hematopoietic diseases Hematopoiesis and Stem Cells Hematopoietic Stem Cell Transplantation Hematopoietic Stem Cells - cytology Medical sciences Mice Mice, Inbred C57BL Spleen - cytology Spleen - immunology T-Lymphocyte Subsets - cytology T-Lymphocyte Subsets - immunology T-Lymphocytes - cytology T-Lymphocytes - immunology T-Lymphocytes - transplantation Thymus Gland - cytology Thymus Gland - immunology Yolk Sac - cytology Yolk Sac - immunology
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