Breast-feeding and Transmission of HIV-1
Breast-feeding substantially increases the risk of HIV-1 transmission from mother to child, and although peripartum antiretroviral therapy prophylaxis significantly decreases the risk of mother-to-child transmission around the time of delivery, this approach does not affect breast-feeding transmissi...
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| Veröffentlicht in: | Journal of acquired immune deficiency syndromes (1999) 2004-02, Vol.35 (2), p.196-202 |
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| container_title | Journal of acquired immune deficiency syndromes (1999) |
| container_volume | 35 |
| creator | John-Stewart, Grace Mbori-Ngacha, Dorothy Ekpini, Rene Janoff, Edward N Nkengasong, John Read, Jennifer S Van de Perre, Phillippe Newell, Marie-Louise |
| description | Breast-feeding substantially increases the risk of HIV-1 transmission from mother to child, and although peripartum antiretroviral therapy prophylaxis significantly decreases the risk of mother-to-child transmission around the time of delivery, this approach does not affect breast-feeding transmission. Increased maternal RNA viral load in plasma and breast milk is strongly associated with increased risk of transmission through breast-feeding, as is breast health, and it has been suggested that exclusive breast-feeding could be associated with lower rates of breast-feeding transmission than mixed feeding of both breast- and other milk or feeds. Transmission through breast-feeding can take place at any point during lactation, and the cumulative probability of acquisition of infection increases with duration of breast-feeding. HIV-1 has been detected in breast milk in cell-free and cellular compartments; infant gut mucosal surfaces are the most likely site at which transmission occurs. Innate and acquired immune factors may act most effectively in combination to prevent primary HIV-1 infection by breast milk. |
| doi_str_mv | 10.1097/00126334-200402010-00015 |
| format | Article |
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Increased maternal RNA viral load in plasma and breast milk is strongly associated with increased risk of transmission through breast-feeding, as is breast health, and it has been suggested that exclusive breast-feeding could be associated with lower rates of breast-feeding transmission than mixed feeding of both breast- and other milk or feeds. Transmission through breast-feeding can take place at any point during lactation, and the cumulative probability of acquisition of infection increases with duration of breast-feeding. HIV-1 has been detected in breast milk in cell-free and cellular compartments; infant gut mucosal surfaces are the most likely site at which transmission occurs. Innate and acquired immune factors may act most effectively in combination to prevent primary HIV-1 infection by breast milk.</description><identifier>ISSN: 1525-4135</identifier><identifier>EISSN: 1944-7884</identifier><identifier>DOI: 10.1097/00126334-200402010-00015</identifier><identifier>PMID: 14722454</identifier><identifier>CODEN: JDSRET</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins, Inc</publisher><subject>Acquired Immunodeficiency Syndrome - prevention & control ; Acquired Immunodeficiency Syndrome - transmission ; AIDS/HIV ; Biological and medical sciences ; Breast Feeding - adverse effects ; Breastfeeding & lactation ; Disease transmission ; Drug Resistance, Viral ; Female ; Fundamental and applied biological sciences. 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Increased maternal RNA viral load in plasma and breast milk is strongly associated with increased risk of transmission through breast-feeding, as is breast health, and it has been suggested that exclusive breast-feeding could be associated with lower rates of breast-feeding transmission than mixed feeding of both breast- and other milk or feeds. Transmission through breast-feeding can take place at any point during lactation, and the cumulative probability of acquisition of infection increases with duration of breast-feeding. HIV-1 has been detected in breast milk in cell-free and cellular compartments; infant gut mucosal surfaces are the most likely site at which transmission occurs. Innate and acquired immune factors may act most effectively in combination to prevent primary HIV-1 infection by breast milk.</description><subject>Acquired Immunodeficiency Syndrome - prevention & control</subject><subject>Acquired Immunodeficiency Syndrome - transmission</subject><subject>AIDS/HIV</subject><subject>Biological and medical sciences</subject><subject>Breast Feeding - adverse effects</subject><subject>Breastfeeding & lactation</subject><subject>Disease transmission</subject><subject>Drug Resistance, Viral</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Health risk assessment</subject><subject>HIV</subject><subject>HIV Infections - prevention & control</subject><subject>HIV Infections - transmission</subject><subject>HIV-1 - drug effects</subject><subject>HIV-1 - isolation & purification</subject><subject>Human immunodeficiency virus</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infant</subject><subject>Infectious Disease Transmission, Vertical - prevention & control</subject><subject>Infectious diseases</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Milk, Human - virology</subject><subject>Miscellaneous</subject><subject>Risk Factors</subject><subject>Viral diseases</subject><subject>Virology</subject><issn>1525-4135</issn><issn>1944-7884</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkl1rFTEQhoNYbHv0L8giKN7ETj43uRG0qC0UelO9DUl20rN1z25Ndi3-e1PPsdWCeJWQeWbImyeENAzeMLDtEQDjWghJOYAEDgwo1DP1iBwwKyVtjZGP615xRSUTap8clnJVCS2lfUL2mWw5l0oekNfvM_oy04TY9eNl48euuch-LJu-lH4amyk1J6dfKHtK9pIfCj7brSvy-eOHi-MTenb-6fT43RmNSlpF29ZaoQP4kALnkanIJKIRBoO2KQWQEYIJITEewHCOou26WuukRZEiiBV5u517vYQNdhHHOfvBXed-4_MPN_ne_V0Z-7W7nL47IQxnoOuAV7sBefq2YJldjRJxGPyI01KcAbCKgfwvyCzXFTQVfPEAvJqWPNZXcFwILaSomVfEbKGYp1IyprsrM3C30txvae5OmvslrbY-_zPyfePOUgVe7gBfoh9S9RP7cs8ppUG3beXklruZhhlz-TosN5jdGv0wr92_Po34Cf7qrNk</recordid><startdate>20040201</startdate><enddate>20040201</enddate><creator>John-Stewart, Grace</creator><creator>Mbori-Ngacha, Dorothy</creator><creator>Ekpini, Rene</creator><creator>Janoff, Edward N</creator><creator>Nkengasong, John</creator><creator>Read, Jennifer S</creator><creator>Van de Perre, Phillippe</creator><creator>Newell, Marie-Louise</creator><general>Lippincott Williams & Wilkins, Inc</general><general>Lippincott Williams & Wilkins</general><general>Lippincott Williams & Wilkins Ovid Technologies</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T2</scope><scope>7T5</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20040201</creationdate><title>Breast-feeding and Transmission of HIV-1</title><author>John-Stewart, Grace ; Mbori-Ngacha, Dorothy ; Ekpini, Rene ; Janoff, Edward N ; Nkengasong, John ; Read, Jennifer S ; Van de Perre, Phillippe ; Newell, Marie-Louise</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5495-779936b0abfb22c15c14ee838eb69ffb04c0b8bbf12b0822e37ddeb6d49e3fc03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Acquired Immunodeficiency Syndrome - prevention & control</topic><topic>Acquired Immunodeficiency Syndrome - transmission</topic><topic>AIDS/HIV</topic><topic>Biological and medical sciences</topic><topic>Breast Feeding - adverse effects</topic><topic>Breastfeeding & lactation</topic><topic>Disease transmission</topic><topic>Drug Resistance, Viral</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Health risk assessment</topic><topic>HIV</topic><topic>HIV Infections - prevention & control</topic><topic>HIV Infections - transmission</topic><topic>HIV-1 - drug effects</topic><topic>HIV-1 - isolation & purification</topic><topic>Human immunodeficiency virus</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infant</topic><topic>Infectious Disease Transmission, Vertical - prevention & control</topic><topic>Infectious diseases</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Milk, Human - virology</topic><topic>Miscellaneous</topic><topic>Risk Factors</topic><topic>Viral diseases</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>John-Stewart, Grace</creatorcontrib><creatorcontrib>Mbori-Ngacha, Dorothy</creatorcontrib><creatorcontrib>Ekpini, Rene</creatorcontrib><creatorcontrib>Janoff, Edward N</creatorcontrib><creatorcontrib>Nkengasong, John</creatorcontrib><creatorcontrib>Read, Jennifer S</creatorcontrib><creatorcontrib>Van de Perre, Phillippe</creatorcontrib><creatorcontrib>Newell, Marie-Louise</creatorcontrib><creatorcontrib>Ghent IAS Working Group on HIV in Women Children</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of acquired immune deficiency syndromes (1999)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>John-Stewart, Grace</au><au>Mbori-Ngacha, Dorothy</au><au>Ekpini, Rene</au><au>Janoff, Edward N</au><au>Nkengasong, John</au><au>Read, Jennifer S</au><au>Van de Perre, Phillippe</au><au>Newell, Marie-Louise</au><aucorp>Ghent IAS Working Group on HIV in Women Children</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Breast-feeding and Transmission of HIV-1</atitle><jtitle>Journal of acquired immune deficiency syndromes (1999)</jtitle><addtitle>J Acquir Immune Defic Syndr</addtitle><date>2004-02-01</date><risdate>2004</risdate><volume>35</volume><issue>2</issue><spage>196</spage><epage>202</epage><pages>196-202</pages><issn>1525-4135</issn><eissn>1944-7884</eissn><coden>JDSRET</coden><abstract>Breast-feeding substantially increases the risk of HIV-1 transmission from mother to child, and although peripartum antiretroviral therapy prophylaxis significantly decreases the risk of mother-to-child transmission around the time of delivery, this approach does not affect breast-feeding transmission. 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| fulltext | fulltext |
| identifier | ISSN: 1525-4135 |
| ispartof | Journal of acquired immune deficiency syndromes (1999), 2004-02, Vol.35 (2), p.196-202 |
| issn | 1525-4135 1944-7884 |
| language | eng |
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| source | MEDLINE; Journals@Ovid LWW Legacy Archive; Journals@Ovid Complete; Free E- Journals |
| subjects | Acquired Immunodeficiency Syndrome - prevention & control Acquired Immunodeficiency Syndrome - transmission AIDS/HIV Biological and medical sciences Breast Feeding - adverse effects Breastfeeding & lactation Disease transmission Drug Resistance, Viral Female Fundamental and applied biological sciences. Psychology Health risk assessment HIV HIV Infections - prevention & control HIV Infections - transmission HIV-1 - drug effects HIV-1 - isolation & purification Human immunodeficiency virus Human viral diseases Humans Infant Infectious Disease Transmission, Vertical - prevention & control Infectious diseases Medical sciences Microbiology Milk, Human - virology Miscellaneous Risk Factors Viral diseases Virology |
| title | Breast-feeding and Transmission of HIV-1 |
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