Formin mDia1 Mediates Vascular Remodeling via Integration of Oxidative and Signal Transduction Pathways

RATIONALE:The mammalian diaphanous-related formin (mDia1), governs microtubule and microfilament dynamics while functioning as an effector for Rho small GTP-binding proteins during key cellular processes such as adhesion, cytokinesis, cell polarity, and morphogenesis. The cytoplasmic domain of the r...

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Veröffentlicht in:	Circulation research 2012-05, Vol.110 (10), p.1279-1293
Hauptverfasser:	Touré, Fatouma, Fritz, Günter, Li, Qing, Rai, Vivek, Daffu, Gurdip, Zou, Yu Shan, Rosario, Rosa, Ramasamy, Ravichandran, Alberts, Arthur S, Yan, Shi Fang, Schmidt, Ann Marie
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Cytoskeleton - physiology Animals Biological and medical sciences Carrier Proteins - genetics Carrier Proteins - metabolism Cell Movement - physiology Cells, Cultured Femoral Artery - injuries Femoral Artery - metabolism Femoral Artery - pathology Fundamental and applied biological sciences. Psychology Glycation End Products, Advanced - metabolism Glycogen Synthase Kinase 3 - metabolism Glycogen Synthase Kinase 3 beta Male Mice Mice, Inbred C57BL Mice, Mutant Strains Microtubules - physiology Muscle, Smooth, Vascular - injuries Muscle, Smooth, Vascular - metabolism Muscle, Smooth, Vascular - pathology NADH, NADPH Oxidoreductases - genetics NADH, NADPH Oxidoreductases - metabolism NADPH Oxidase 1 Neointima - metabolism Neointima - pathology Oxidative Stress - physiology Proto-Oncogene Proteins pp60(c-src) - genetics Proto-Oncogene Proteins pp60(c-src) - metabolism Receptor for Advanced Glycation End Products Receptors, Immunologic - metabolism Signal Transduction - physiology Vertebrates: cardiovascular system
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