Increased H1N1 Infection Rate in Children with Asthma
The 2009 H1N1 flu appeared to cause more severe cold symptoms during the 2009-2010 flu season. We evaluated H1N1 infections during peak viral season in children with and without asthma to determine whether the H1N1 infectivity rate and illness severity were greater in subjects with asthma. One hundr...
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| Veröffentlicht in: | American journal of respiratory and critical care medicine 2012-06, Vol.185 (12), p.1275-1279 |
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| creator | KLOEPFER, Kirsten M OLENEC, Jaime P WAI MING LEE GUIYAN LIU VRTIS, Rose F ROBERG, Kathy A EVANS, Michael D GANGNON, Ronald E LEMANSKE, Robert F GERN, James E |
| description | The 2009 H1N1 flu appeared to cause more severe cold symptoms during the 2009-2010 flu season.
We evaluated H1N1 infections during peak viral season in children with and without asthma to determine whether the H1N1 infectivity rate and illness severity were greater in subjects with asthma.
One hundred and eighty children, 4-12 years of age, provided eight consecutive weekly nasal mucus samples from September 5 through October 24, 2009, and scored cold and asthma symptoms daily. Viral diagnostics were performed for all nasal samples.
One hundred and sixty-one children (95 with asthma, 66 without asthma) completed at least 6 of the 8 nasal samples. The incidence of H1N1 infection was significantly higher in children with asthma (41%) than in children without asthma (24%; odds ratio, 4; 95% confidence interval, 1.8-9; P < 0.001), but rates of human rhinovirus infection (90% each) and other viral infections (47 vs. 41%) were similar. In children with asthma, there was a nonsignificant trend for increased loss of asthma control during H1N1 infections compared with human rhinovirus infections (38 vs. 21%; odds ratio, 2.6; 95% confidence interval, 0.9-7.2; P = 0.07).
During peak 2009 H1N1 flu season, children with asthma were infected almost twice as often with H1N1 compared with other respiratory viruses. H1N1 infection also caused increased severity of cold symptoms compared with other viral infections. Given the increased susceptibility of children with asthma to infection, these findings reinforce the need for yearly influenza vaccination to prevent infection, and raise new questions about the mechanism for enhanced susceptibility to influenza infection in asthma. |
| doi_str_mv | 10.1164/rccm.201109-1635OC |
| format | Article |
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We evaluated H1N1 infections during peak viral season in children with and without asthma to determine whether the H1N1 infectivity rate and illness severity were greater in subjects with asthma.
One hundred and eighty children, 4-12 years of age, provided eight consecutive weekly nasal mucus samples from September 5 through October 24, 2009, and scored cold and asthma symptoms daily. Viral diagnostics were performed for all nasal samples.
One hundred and sixty-one children (95 with asthma, 66 without asthma) completed at least 6 of the 8 nasal samples. The incidence of H1N1 infection was significantly higher in children with asthma (41%) than in children without asthma (24%; odds ratio, 4; 95% confidence interval, 1.8-9; P < 0.001), but rates of human rhinovirus infection (90% each) and other viral infections (47 vs. 41%) were similar. In children with asthma, there was a nonsignificant trend for increased loss of asthma control during H1N1 infections compared with human rhinovirus infections (38 vs. 21%; odds ratio, 2.6; 95% confidence interval, 0.9-7.2; P = 0.07).
During peak 2009 H1N1 flu season, children with asthma were infected almost twice as often with H1N1 compared with other respiratory viruses. H1N1 infection also caused increased severity of cold symptoms compared with other viral infections. Given the increased susceptibility of children with asthma to infection, these findings reinforce the need for yearly influenza vaccination to prevent infection, and raise new questions about the mechanism for enhanced susceptibility to influenza infection in asthma.</description><identifier>ISSN: 1073-449X</identifier><identifier>EISSN: 1535-4970</identifier><identifier>DOI: 10.1164/rccm.201109-1635OC</identifier><identifier>PMID: 22366048</identifier><language>eng</language><publisher>New York, NY: American Thoracic Society</publisher><subject>Age Distribution ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Asthma ; Asthma - diagnosis ; Asthma - epidemiology ; Biological and medical sciences ; Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis ; Case-Control Studies ; Chi-Square Distribution ; Child ; Child, Preschool ; Comorbidity ; Confidence intervals ; Cytokines ; Disease Susceptibility - epidemiology ; Enrollments ; Female ; Humans ; Incidence ; Infections ; Influenza A Virus, H1N1 Subtype - isolation & purification ; Influenza, Human - diagnosis ; Influenza, Human - epidemiology ; Intensive care medicine ; Logistic Models ; Male ; Medical sciences ; Pandemics ; Picornaviridae Infections - diagnosis ; Picornaviridae Infections - epidemiology ; Polymerase chain reaction ; Retrospective Studies ; Rhinovirus - isolation & purification ; Risk Assessment ; Seasons ; Severity of Illness Index ; Sex Distribution ; Statistics, Nonparametric ; Swine flu ; Transfusions. Complications. Transfusion reactions. Cell and gene therapy ; United States - epidemiology ; Vaccines ; Viral infections ; Viruses</subject><ispartof>American journal of respiratory and critical care medicine, 2012-06, Vol.185 (12), p.1275-1279</ispartof><rights>2015 INIST-CNRS</rights><rights>Copyright American Thoracic Society Jun 15, 2012</rights><rights>Copyright © 2012 by the American Thoracic Society 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c460t-ba4b5939d2cd491cb55f88224df78656901d6fa054b570f140dcfad734f82ef53</citedby><cites>FETCH-LOGICAL-c460t-ba4b5939d2cd491cb55f88224df78656901d6fa054b570f140dcfad734f82ef53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,4025,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25990082$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22366048$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KLOEPFER, Kirsten M</creatorcontrib><creatorcontrib>OLENEC, Jaime P</creatorcontrib><creatorcontrib>WAI MING LEE</creatorcontrib><creatorcontrib>GUIYAN LIU</creatorcontrib><creatorcontrib>VRTIS, Rose F</creatorcontrib><creatorcontrib>ROBERG, Kathy A</creatorcontrib><creatorcontrib>EVANS, Michael D</creatorcontrib><creatorcontrib>GANGNON, Ronald E</creatorcontrib><creatorcontrib>LEMANSKE, Robert F</creatorcontrib><creatorcontrib>GERN, James E</creatorcontrib><title>Increased H1N1 Infection Rate in Children with Asthma</title><title>American journal of respiratory and critical care medicine</title><addtitle>Am J Respir Crit Care Med</addtitle><description>The 2009 H1N1 flu appeared to cause more severe cold symptoms during the 2009-2010 flu season.
We evaluated H1N1 infections during peak viral season in children with and without asthma to determine whether the H1N1 infectivity rate and illness severity were greater in subjects with asthma.
One hundred and eighty children, 4-12 years of age, provided eight consecutive weekly nasal mucus samples from September 5 through October 24, 2009, and scored cold and asthma symptoms daily. Viral diagnostics were performed for all nasal samples.
One hundred and sixty-one children (95 with asthma, 66 without asthma) completed at least 6 of the 8 nasal samples. The incidence of H1N1 infection was significantly higher in children with asthma (41%) than in children without asthma (24%; odds ratio, 4; 95% confidence interval, 1.8-9; P < 0.001), but rates of human rhinovirus infection (90% each) and other viral infections (47 vs. 41%) were similar. In children with asthma, there was a nonsignificant trend for increased loss of asthma control during H1N1 infections compared with human rhinovirus infections (38 vs. 21%; odds ratio, 2.6; 95% confidence interval, 0.9-7.2; P = 0.07).
During peak 2009 H1N1 flu season, children with asthma were infected almost twice as often with H1N1 compared with other respiratory viruses. H1N1 infection also caused increased severity of cold symptoms compared with other viral infections. Given the increased susceptibility of children with asthma to infection, these findings reinforce the need for yearly influenza vaccination to prevent infection, and raise new questions about the mechanism for enhanced susceptibility to influenza infection in asthma.</description><subject>Age Distribution</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Asthma</subject><subject>Asthma - diagnosis</subject><subject>Asthma - epidemiology</subject><subject>Biological and medical sciences</subject><subject>Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis</subject><subject>Case-Control Studies</subject><subject>Chi-Square Distribution</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Comorbidity</subject><subject>Confidence intervals</subject><subject>Cytokines</subject><subject>Disease Susceptibility - epidemiology</subject><subject>Enrollments</subject><subject>Female</subject><subject>Humans</subject><subject>Incidence</subject><subject>Infections</subject><subject>Influenza A Virus, H1N1 Subtype - isolation & purification</subject><subject>Influenza, Human - diagnosis</subject><subject>Influenza, Human - epidemiology</subject><subject>Intensive care medicine</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pandemics</subject><subject>Picornaviridae Infections - diagnosis</subject><subject>Picornaviridae Infections - epidemiology</subject><subject>Polymerase chain reaction</subject><subject>Retrospective Studies</subject><subject>Rhinovirus - isolation & purification</subject><subject>Risk Assessment</subject><subject>Seasons</subject><subject>Severity of Illness Index</subject><subject>Sex Distribution</subject><subject>Statistics, Nonparametric</subject><subject>Swine flu</subject><subject>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</subject><subject>United States - epidemiology</subject><subject>Vaccines</subject><subject>Viral infections</subject><subject>Viruses</subject><issn>1073-449X</issn><issn>1535-4970</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpdkV1rFDEUhoMotlb_gBcyIIXeTD0nXzO5KZTFtgvFgih4F7L5cFNmMm0yW-m_N-uu9ePqBM5zXs7JQ8hbhFNEyT9ka8dTCoigWpRM3CyekUMUTLRcdfC8vqFjLefq2wF5VcotANIe4SU5oJRJCbw_JGKZbPameNdc4Sdslil4O8cpNZ_N7JuYmsU6Di771PyI87o5L_N6NK_Ji2CG4t_s6xH5evHxy-Kqvb65XC7Or1vLJcztyvCVUEw5ah1XaFdChL6nlLvQ9VJIBehkMCAq1kFADs4G4zrGQ099EOyInO1y7zar0Tvr05zNoO9yHE1-1JOJ-t9Oimv9fXrQjPVIGasBJ_uAPN1vfJn1GIv1w2CSnzZFI1Csn0J5V9H3_6G30yanet4vquZJtd2I7iibp1KyD0_LIOitFb21ondW9M5KHXr39xlPI781VOB4D5hizRCySTaWP5xQCqCn7Cdh8JRR</recordid><startdate>20120615</startdate><enddate>20120615</enddate><creator>KLOEPFER, Kirsten M</creator><creator>OLENEC, Jaime P</creator><creator>WAI MING LEE</creator><creator>GUIYAN LIU</creator><creator>VRTIS, Rose F</creator><creator>ROBERG, Kathy A</creator><creator>EVANS, Michael D</creator><creator>GANGNON, Ronald E</creator><creator>LEMANSKE, Robert F</creator><creator>GERN, James E</creator><general>American Thoracic Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20120615</creationdate><title>Increased H1N1 Infection Rate in Children with Asthma</title><author>KLOEPFER, Kirsten M ; OLENEC, Jaime P ; WAI MING LEE ; GUIYAN LIU ; VRTIS, Rose F ; ROBERG, Kathy A ; EVANS, Michael D ; GANGNON, Ronald E ; LEMANSKE, Robert F ; GERN, James E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c460t-ba4b5939d2cd491cb55f88224df78656901d6fa054b570f140dcfad734f82ef53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Age Distribution</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Asthma</topic><topic>Asthma - diagnosis</topic><topic>Asthma - epidemiology</topic><topic>Biological and medical sciences</topic><topic>Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis</topic><topic>Case-Control Studies</topic><topic>Chi-Square Distribution</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Comorbidity</topic><topic>Confidence intervals</topic><topic>Cytokines</topic><topic>Disease Susceptibility - epidemiology</topic><topic>Enrollments</topic><topic>Female</topic><topic>Humans</topic><topic>Incidence</topic><topic>Infections</topic><topic>Influenza A Virus, H1N1 Subtype - isolation & purification</topic><topic>Influenza, Human - diagnosis</topic><topic>Influenza, Human - epidemiology</topic><topic>Intensive care medicine</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pandemics</topic><topic>Picornaviridae Infections - diagnosis</topic><topic>Picornaviridae Infections - epidemiology</topic><topic>Polymerase chain reaction</topic><topic>Retrospective Studies</topic><topic>Rhinovirus - isolation & purification</topic><topic>Risk Assessment</topic><topic>Seasons</topic><topic>Severity of Illness Index</topic><topic>Sex Distribution</topic><topic>Statistics, Nonparametric</topic><topic>Swine flu</topic><topic>Transfusions. Complications. Transfusion reactions. 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We evaluated H1N1 infections during peak viral season in children with and without asthma to determine whether the H1N1 infectivity rate and illness severity were greater in subjects with asthma.
One hundred and eighty children, 4-12 years of age, provided eight consecutive weekly nasal mucus samples from September 5 through October 24, 2009, and scored cold and asthma symptoms daily. Viral diagnostics were performed for all nasal samples.
One hundred and sixty-one children (95 with asthma, 66 without asthma) completed at least 6 of the 8 nasal samples. The incidence of H1N1 infection was significantly higher in children with asthma (41%) than in children without asthma (24%; odds ratio, 4; 95% confidence interval, 1.8-9; P < 0.001), but rates of human rhinovirus infection (90% each) and other viral infections (47 vs. 41%) were similar. In children with asthma, there was a nonsignificant trend for increased loss of asthma control during H1N1 infections compared with human rhinovirus infections (38 vs. 21%; odds ratio, 2.6; 95% confidence interval, 0.9-7.2; P = 0.07).
During peak 2009 H1N1 flu season, children with asthma were infected almost twice as often with H1N1 compared with other respiratory viruses. H1N1 infection also caused increased severity of cold symptoms compared with other viral infections. Given the increased susceptibility of children with asthma to infection, these findings reinforce the need for yearly influenza vaccination to prevent infection, and raise new questions about the mechanism for enhanced susceptibility to influenza infection in asthma.</abstract><cop>New York, NY</cop><pub>American Thoracic Society</pub><pmid>22366048</pmid><doi>10.1164/rccm.201109-1635OC</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Age Distribution Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Asthma Asthma - diagnosis Asthma - epidemiology Biological and medical sciences Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis Case-Control Studies Chi-Square Distribution Child Child, Preschool Comorbidity Confidence intervals Cytokines Disease Susceptibility - epidemiology Enrollments Female Humans Incidence Infections Influenza A Virus, H1N1 Subtype - isolation & purification Influenza, Human - diagnosis Influenza, Human - epidemiology Intensive care medicine Logistic Models Male Medical sciences Pandemics Picornaviridae Infections - diagnosis Picornaviridae Infections - epidemiology Polymerase chain reaction Retrospective Studies Rhinovirus - isolation & purification Risk Assessment Seasons Severity of Illness Index Sex Distribution Statistics, Nonparametric Swine flu Transfusions. Complications. Transfusion reactions. Cell and gene therapy United States - epidemiology Vaccines Viral infections Viruses |
| title | Increased H1N1 Infection Rate in Children with Asthma |
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