Ack1-mediated Androgen Receptor Phosphorylation Modulates Radiation Resistance in Castration-resistant Prostate Cancer

Androgen deprivation therapy has been the standard of care in prostate cancer due to its effectiveness in initial stages. However, the disease recurs, and this recurrent cancer is referred to as castration-resistant prostate cancer (CRPC). Radiotherapy is the treatment of choice; however, in additio...

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Veröffentlicht in:	The Journal of biological chemistry 2012-06, Vol.287 (26), p.22112-22122
Hauptverfasser:	Mahajan, Kiran, Coppola, Domenico, Rawal, Bhupendra, Chen, Y. Ann, Lawrence, Harshani R., Engelman, Robert W., Lawrence, Nicholas J., Mahajan, Nupam P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Androgen Receptor Animals Ataxia Telangiectasia Mutated Proteins Cancer Biology Cell Cycle Proteins - metabolism DNA Damage DNA-Binding Proteins - metabolism Enhancer Elements, Genetic Humans Immunohistochemistry - methods Inhibitory Concentration 50 Male Mice Mice, Transgenic Neoplasm Transplantation Phosphorylation Prostate Cancer Prostatic Neoplasms - drug therapy Prostatic Neoplasms - radiotherapy Protein-Serine-Threonine Kinases - metabolism Protein-Tyrosine Kinases - metabolism Radiation Biology Radiation Tolerance Receptors, Androgen - metabolism Signal Transduction Tumor Suppressor Proteins - metabolism Tyrosine Protein Kinase (Tyrosine Kinase)
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