High ERK Protein Expression Levels Correlate with Shorter Survival in Triple‐Negative Breast Cancer Patients

The mitogen‐activated protein kinase (MAPK) signaling pathway is known to be activated in triple‐negative breast cancer (TNBC). Extracellular signal–related kinase (ERK), a member of the MAPK pathway, promotes cell proliferation, angiogenesis, cell differentiation, and cell survival. To assess the p...

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Veröffentlicht in:	The oncologist (Dayton, Ohio) Ohio), 2012-06, Vol.17 (6), p.766-774
Hauptverfasser:	Bartholomeusz, Chandra, Gonzalez‐Angulo, Ana M., Liu, Ping, Hayashi, Naoki, Lluch, Ana, Ferrer‐Lozano, Jaime, Hortobágyi, Gabriel N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Breast Cancer Breast Neoplasms - diagnosis Breast Neoplasms - mortality Breast Neoplasms - pathology ERK Female Gene Expression Regulation, Neoplastic Humans Middle Aged Mitogen-Activated Protein Kinase 1 - genetics Mitogen-Activated Protein Kinase 1 - metabolism Multivariate Analysis PEA‐15 Prognosis Proportional Hazards Models Retrospective Studies RPPA Survival Triple‐negative breast cancer
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