Antiaging Gene Klotho Enhances Glucose-Induced Insulin Secretion by Up-Regulating Plasma Membrane Levels of TRPV2 in MIN6 β-Cells

Klotho is a recently discovered antiaging gene. Klotho is expressed in mouse pancreatic islets and in insulinoma β-cells (MIN6 β-cells). The purpose of this study was to investigate whether Klotho plays a role in the regulation of insulin secretion in MIN6 β-cells by overexpression and silencing of...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2012-07, Vol.153 (7), p.3029-3039
Hauptverfasser:	Lin, Yi, Sun, Zhongjie
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Animals Beta cells Biological and medical sciences Calcium Calcium (intracellular) Calcium - metabolism Calcium Channels - metabolism Cell Membrane - metabolism Cytosol - metabolism Diabetes-Insulin-Glucagon-Gastrointestinal Fundamental and applied biological sciences. Psychology Gene Expression Regulation Glucose Glucose - metabolism Glucuronidase - metabolism Insulin Insulin - metabolism Insulin Secretion Insulin-Secreting Cells - cytology Insulinoma Islets of Langerhans - cytology Klotho protein Membranes Mice Plasma RNA, Small Interfering - metabolism siRNA Transient receptor potential proteins TRPV Cation Channels - metabolism Up-Regulation Vertebrates: endocrinology
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