Behavioral changes in mice caused by Toxoplasma gondii invasion of brain
Toxoplasma gondii , a protozoan parasite, is capable of infecting a broad range of intermediate warm-blooded hosts including humans. The parasite undergoes sexual reproduction resulting in genetic variability only in the intestine of the definitive host (a member of the cat family). The parasite see...
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| Veröffentlicht in: | Parasitology research (1987) 2012-07, Vol.111 (1), p.53-58 |
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| container_title | Parasitology research (1987) |
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| creator | Gatkowska, Justyna Wieczorek, Marek Dziadek, Bozena Dzitko, Katarzyna Dlugonska, Henryka |
| description | Toxoplasma gondii
, a protozoan parasite, is capable of infecting a broad range of intermediate warm-blooded hosts including humans. The parasite undergoes sexual reproduction resulting in genetic variability only in the intestine of the definitive host (a member of the cat family). The parasite seems to be capable of altering the natural behavior of the host to favor its transmission in the environment. The aim of this study was to evaluate the number of parasite cysts formed in the hippocampus and amygdala of experimentally infected mice as these regions are involved in defense behaviors control and emotion processing, and to assess the influence of the infection on mice behavior. The obtained results revealed the presence of parasite cysts both in the hippocampus and the amygdala of infected mice; however, no clear region-dependent distribution was observed. Furthermore, infected mice showed significantly diminished exploratory activity described by climbing and rearing, smaller preference for the central, more exposed part of the OF arena and engaged in less grooming behavior compared to uninfected controls. |
| doi_str_mv | 10.1007/s00436-011-2800-y |
| format | Article |
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, a protozoan parasite, is capable of infecting a broad range of intermediate warm-blooded hosts including humans. The parasite undergoes sexual reproduction resulting in genetic variability only in the intestine of the definitive host (a member of the cat family). The parasite seems to be capable of altering the natural behavior of the host to favor its transmission in the environment. The aim of this study was to evaluate the number of parasite cysts formed in the hippocampus and amygdala of experimentally infected mice as these regions are involved in defense behaviors control and emotion processing, and to assess the influence of the infection on mice behavior. The obtained results revealed the presence of parasite cysts both in the hippocampus and the amygdala of infected mice; however, no clear region-dependent distribution was observed. Furthermore, infected mice showed significantly diminished exploratory activity described by climbing and rearing, smaller preference for the central, more exposed part of the OF arena and engaged in less grooming behavior compared to uninfected controls.</description><identifier>ISSN: 0932-0113</identifier><identifier>EISSN: 1432-1955</identifier><identifier>DOI: 10.1007/s00436-011-2800-y</identifier><identifier>PMID: 22223035</identifier><identifier>CODEN: PARREZ</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>amygdala ; Amygdala - parasitology ; Amygdala - pathology ; Animals ; Biological and medical sciences ; Biomedical and Life Sciences ; Biomedicine ; Brain ; Disease Models, Animal ; Felidae ; Fundamental and applied biological sciences. Psychology ; General aspects ; General aspects and techniques. Study of several systematic groups. Models ; genetic variation ; Health aspects ; hippocampus ; Hippocampus - parasitology ; Hippocampus - pathology ; Host-parasite relationships ; humans ; Immunology ; intermediate hosts ; intestines ; Invertebrates ; Male ; Medical Microbiology ; Mental Disorders ; Mental Disorders - parasitology ; Mice ; Mice, Inbred C57BL ; Microbiology ; Original Paper ; parasites ; parasitology ; pathogenicity ; pathology ; Physiological aspects ; physiopathology ; sexual reproduction ; Toxoplasma ; Toxoplasma - pathogenicity ; Toxoplasma gondii ; Toxoplasmosis, Animal ; Toxoplasmosis, Animal - parasitology ; Toxoplasmosis, Animal - pathology ; Toxoplasmosis, Animal - physiopathology</subject><ispartof>Parasitology research (1987), 2012-07, Vol.111 (1), p.53-58</ispartof><rights>The Author(s) 2012</rights><rights>2015 INIST-CNRS</rights><rights>COPYRIGHT 2012 Springer</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c599t-52a9d4fae0ea43278760a9014b3fa02f12d98086576585d9dd5a4fe34b9e7e1b3</citedby><cites>FETCH-LOGICAL-c599t-52a9d4fae0ea43278760a9014b3fa02f12d98086576585d9dd5a4fe34b9e7e1b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00436-011-2800-y$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00436-011-2800-y$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26117408$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22223035$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gatkowska, Justyna</creatorcontrib><creatorcontrib>Wieczorek, Marek</creatorcontrib><creatorcontrib>Dziadek, Bozena</creatorcontrib><creatorcontrib>Dzitko, Katarzyna</creatorcontrib><creatorcontrib>Dlugonska, Henryka</creatorcontrib><title>Behavioral changes in mice caused by Toxoplasma gondii invasion of brain</title><title>Parasitology research (1987)</title><addtitle>Parasitol Res</addtitle><addtitle>Parasitol Res</addtitle><description>Toxoplasma gondii
, a protozoan parasite, is capable of infecting a broad range of intermediate warm-blooded hosts including humans. The parasite undergoes sexual reproduction resulting in genetic variability only in the intestine of the definitive host (a member of the cat family). The parasite seems to be capable of altering the natural behavior of the host to favor its transmission in the environment. The aim of this study was to evaluate the number of parasite cysts formed in the hippocampus and amygdala of experimentally infected mice as these regions are involved in defense behaviors control and emotion processing, and to assess the influence of the infection on mice behavior. The obtained results revealed the presence of parasite cysts both in the hippocampus and the amygdala of infected mice; however, no clear region-dependent distribution was observed. Furthermore, infected mice showed significantly diminished exploratory activity described by climbing and rearing, smaller preference for the central, more exposed part of the OF arena and engaged in less grooming behavior compared to uninfected controls.</description><subject>amygdala</subject><subject>Amygdala - parasitology</subject><subject>Amygdala - pathology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Brain</subject><subject>Disease Models, Animal</subject><subject>Felidae</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General aspects</subject><subject>General aspects and techniques. Study of several systematic groups. Models</subject><subject>genetic variation</subject><subject>Health aspects</subject><subject>hippocampus</subject><subject>Hippocampus - parasitology</subject><subject>Hippocampus - pathology</subject><subject>Host-parasite relationships</subject><subject>humans</subject><subject>Immunology</subject><subject>intermediate hosts</subject><subject>intestines</subject><subject>Invertebrates</subject><subject>Male</subject><subject>Medical Microbiology</subject><subject>Mental Disorders</subject><subject>Mental Disorders - parasitology</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Microbiology</subject><subject>Original Paper</subject><subject>parasites</subject><subject>parasitology</subject><subject>pathogenicity</subject><subject>pathology</subject><subject>Physiological aspects</subject><subject>physiopathology</subject><subject>sexual reproduction</subject><subject>Toxoplasma</subject><subject>Toxoplasma - pathogenicity</subject><subject>Toxoplasma gondii</subject><subject>Toxoplasmosis, Animal</subject><subject>Toxoplasmosis, Animal - parasitology</subject><subject>Toxoplasmosis, Animal - pathology</subject><subject>Toxoplasmosis, Animal - physiopathology</subject><issn>0932-0113</issn><issn>1432-1955</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><recordid>eNqFkU1rFDEYgIModlv9AV5kQIReRt98z1yEWtQKBS_1HN7JZHZTZpI12Vm6_94ss1a9aC4JvM_7lYeQVxTeUQD9PgMIrmqgtGYNQH14QlZUcFbTVsqnZAVteZcoPyPnOd8DUK2EeE7OWDkcuFyRm49ug3sfE46V3WBYu1z5UE3eusrinF1fdYfqLj7E7Yh5wmodQ-99YfaYfQxVHKouoQ8vyLMBx-xenu4L8v3zp7vrm_r225ev11e3tZVtu6slw7YXAzpwWCbVjVaALVDR8QGBDZT1bQONklrJRvZt30sUg-Oia512tOMX5MNSdzt3k-utC7syu9kmP2E6mIje_B0JfmPWcW84103DeSlweSqQ4o_Z5Z2ZfLZuHDG4OGdDBQPKlChf-18UGBWScgUFfbOgaxyd8WGIpbk94uaKgzqaULpQdKFsijknNzzOTcEclZpFqSnSzFGpOZSc138u_Jjxy2EB3p4AzBbHIWGwPv_mFKVaQFM4tnC5hIroZO7jnEKR9Y_uPwFyz7gF</recordid><startdate>20120701</startdate><enddate>20120701</enddate><creator>Gatkowska, Justyna</creator><creator>Wieczorek, Marek</creator><creator>Dziadek, Bozena</creator><creator>Dzitko, Katarzyna</creator><creator>Dlugonska, Henryka</creator><general>Springer-Verlag</general><general>Springer</general><scope>C6C</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope></search><sort><creationdate>20120701</creationdate><title>Behavioral changes in mice caused by Toxoplasma gondii invasion of brain</title><author>Gatkowska, Justyna ; Wieczorek, Marek ; Dziadek, Bozena ; Dzitko, Katarzyna ; Dlugonska, Henryka</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c599t-52a9d4fae0ea43278760a9014b3fa02f12d98086576585d9dd5a4fe34b9e7e1b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>amygdala</topic><topic>Amygdala - parasitology</topic><topic>Amygdala - pathology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Brain</topic><topic>Disease Models, Animal</topic><topic>Felidae</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General aspects</topic><topic>General aspects and techniques. Study of several systematic groups. Models</topic><topic>genetic variation</topic><topic>Health aspects</topic><topic>hippocampus</topic><topic>Hippocampus - parasitology</topic><topic>Hippocampus - pathology</topic><topic>Host-parasite relationships</topic><topic>humans</topic><topic>Immunology</topic><topic>intermediate hosts</topic><topic>intestines</topic><topic>Invertebrates</topic><topic>Male</topic><topic>Medical Microbiology</topic><topic>Mental Disorders</topic><topic>Mental Disorders - parasitology</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Microbiology</topic><topic>Original Paper</topic><topic>parasites</topic><topic>parasitology</topic><topic>pathogenicity</topic><topic>pathology</topic><topic>Physiological aspects</topic><topic>physiopathology</topic><topic>sexual reproduction</topic><topic>Toxoplasma</topic><topic>Toxoplasma - pathogenicity</topic><topic>Toxoplasma gondii</topic><topic>Toxoplasmosis, Animal</topic><topic>Toxoplasmosis, Animal - parasitology</topic><topic>Toxoplasmosis, Animal - pathology</topic><topic>Toxoplasmosis, Animal - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gatkowska, Justyna</creatorcontrib><creatorcontrib>Wieczorek, Marek</creatorcontrib><creatorcontrib>Dziadek, Bozena</creatorcontrib><creatorcontrib>Dzitko, Katarzyna</creatorcontrib><creatorcontrib>Dlugonska, Henryka</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Parasitology research (1987)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gatkowska, Justyna</au><au>Wieczorek, Marek</au><au>Dziadek, Bozena</au><au>Dzitko, Katarzyna</au><au>Dlugonska, Henryka</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Behavioral changes in mice caused by Toxoplasma gondii invasion of brain</atitle><jtitle>Parasitology research (1987)</jtitle><stitle>Parasitol Res</stitle><addtitle>Parasitol Res</addtitle><date>2012-07-01</date><risdate>2012</risdate><volume>111</volume><issue>1</issue><spage>53</spage><epage>58</epage><pages>53-58</pages><issn>0932-0113</issn><eissn>1432-1955</eissn><coden>PARREZ</coden><abstract>Toxoplasma gondii
, a protozoan parasite, is capable of infecting a broad range of intermediate warm-blooded hosts including humans. The parasite undergoes sexual reproduction resulting in genetic variability only in the intestine of the definitive host (a member of the cat family). The parasite seems to be capable of altering the natural behavior of the host to favor its transmission in the environment. The aim of this study was to evaluate the number of parasite cysts formed in the hippocampus and amygdala of experimentally infected mice as these regions are involved in defense behaviors control and emotion processing, and to assess the influence of the infection on mice behavior. The obtained results revealed the presence of parasite cysts both in the hippocampus and the amygdala of infected mice; however, no clear region-dependent distribution was observed. Furthermore, infected mice showed significantly diminished exploratory activity described by climbing and rearing, smaller preference for the central, more exposed part of the OF arena and engaged in less grooming behavior compared to uninfected controls.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>22223035</pmid><doi>10.1007/s00436-011-2800-y</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Parasitology research (1987), 2012-07, Vol.111 (1), p.53-58 |
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| subjects | amygdala Amygdala - parasitology Amygdala - pathology Animals Biological and medical sciences Biomedical and Life Sciences Biomedicine Brain Disease Models, Animal Felidae Fundamental and applied biological sciences. Psychology General aspects General aspects and techniques. Study of several systematic groups. Models genetic variation Health aspects hippocampus Hippocampus - parasitology Hippocampus - pathology Host-parasite relationships humans Immunology intermediate hosts intestines Invertebrates Male Medical Microbiology Mental Disorders Mental Disorders - parasitology Mice Mice, Inbred C57BL Microbiology Original Paper parasites parasitology pathogenicity pathology Physiological aspects physiopathology sexual reproduction Toxoplasma Toxoplasma - pathogenicity Toxoplasma gondii Toxoplasmosis, Animal Toxoplasmosis, Animal - parasitology Toxoplasmosis, Animal - pathology Toxoplasmosis, Animal - physiopathology |
| title | Behavioral changes in mice caused by Toxoplasma gondii invasion of brain |
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