The impact of early monitored management on survival in hospitalized adult Ugandan patients with severe sepsis: A prospective intervention study
In sub-Saharan Africa, sepsis is an important cause of mortality. Optimal sepsis management including fluid resuscitation, early antibiotic administration, and patient monitoring is limited by lack of supplies and skilled health workers. OBJECTIVE:To evaluate whether early, monitored sepsis manageme...
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| Veröffentlicht in: | Critical care medicine 2012-07, Vol.40 (7), p.2050-2058 |
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| creator | Jacob, Shevin T Banura, Patrick Baeten, Jared M Moore, Christopher C Meya, David Nakiyingi, Lydia Burke, Rebecca Horton, Cheryl Lynn Iga, Boaz Wald, Anna Reynolds, Steven J Mayanja-Kizza, Harriet Scheld, W Michael |
| description | In sub-Saharan Africa, sepsis is an important cause of mortality. Optimal sepsis management including fluid resuscitation, early antibiotic administration, and patient monitoring is limited by lack of supplies and skilled health workers.
OBJECTIVE:To evaluate whether early, monitored sepsis management provided by a study medical officer can improve survival among patients with severe sepsis admitted to two public hospitals in Uganda.
DESIGN, SETTING, AND PATIENTS:A prospective before and after study of an intervention cohort (n = 426) with severe sepsis receiving early, monitored sepsis management compared to an observation cohort (n = 245) of similarly ill patients with severe sepsis receiving standard management after admission to the medical wards of two Ugandan hospitals.
INTERVENTION:Early sepsis management provided by a dedicated study medical officer comprising fluid resuscitation, early antibiotics, and regular monitoring in the first 6 hrs of hospitalization.
MEASUREMENTS:Kaplan-Meier survival and unadjusted and adjusted Cox proportional hazards analysis were used to compare the effect of early, monitored sepsis management on 30-day mortality between the intervention cohort (enrolled May 2008 to May 2009) and observation cohort (enrolled July 2006 to November 2006).
RESULTS:The majority (86%) of patients in both cohorts were human immuno-deficiency virus-infected. Median fluid volume provided in the first 6 hrs of hospitalization was higher in intervention than observation cohort patients (3000 mL vs. 500 mL, p < .001) and a greater proportion of intervention cohort patients received antibacterial therapy in |
| doi_str_mv | 10.1097/CCM.0b013e31824e65d7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3378757</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1033533239</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5266-1750f4b585e77d9c0b04bdf6844045a2ec9cc611b9e91d8b9c94bae7b031dfb23</originalsourceid><addsrcrecordid>eNpdkdtu1DAQhi0EomXhDRDyDVJvUnxKHHOBVK04SUXctNeW40w2BueA7WS1PAWPjFddWsA3I3u-f2Y8P0IvKbmkRMk32-2XS9IQyoHTmgmoylY-Que05KQgTPHH6JwQRQouFD9Dz2L8RggVpeRP0RljZSVUWZ-jXzc9YDfMxiY8dRhM8Ac8TKNLU4AWD2Y0OxhgzNkRxyWsbjUeuxH3U5xdMt79zJhpF5_w7c6MrRnxbJLLioj3LvU4wgoBcpiji2_xFZ5DloJNbs2dxwRhzbA7lk9Le3iOnnTGR3hxiht0--H9zfZTcf314-ft1XVhS1ZVBZUl6URT1iVI2SqbNyGatqtqIYgoDQOrrK0obRQo2taNsko0BmRDOG27hvENendXd16aAVqbZwjG6zm4wYSDnozT_2ZG1-vdtGrOZS3zGjfo4lQgTD8WiEkPLlrw3owwLVFTwnnJOeMqo-IOtfnrMUB334YSfTRTZzP1_2Zm2au_R7wX_XEvA69PgInW-C6Y0br4wFVECsbZQ__95PO-43e_7CHoHoxPvSb5cCaqghHKiMy34vhU8d9pA71h</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1033533239</pqid></control><display><type>article</type><title>The impact of early monitored management on survival in hospitalized adult Ugandan patients with severe sepsis: A prospective intervention study</title><source>MEDLINE</source><source>Journals@Ovid Complete</source><creator>Jacob, Shevin T ; Banura, Patrick ; Baeten, Jared M ; Moore, Christopher C ; Meya, David ; Nakiyingi, Lydia ; Burke, Rebecca ; Horton, Cheryl Lynn ; Iga, Boaz ; Wald, Anna ; Reynolds, Steven J ; Mayanja-Kizza, Harriet ; Scheld, W Michael</creator><creatorcontrib>Jacob, Shevin T ; Banura, Patrick ; Baeten, Jared M ; Moore, Christopher C ; Meya, David ; Nakiyingi, Lydia ; Burke, Rebecca ; Horton, Cheryl Lynn ; Iga, Boaz ; Wald, Anna ; Reynolds, Steven J ; Mayanja-Kizza, Harriet ; Scheld, W Michael ; Promoting Resource-Limited Interventions for Sepsis Management in Uganda Study Group</creatorcontrib><description>In sub-Saharan Africa, sepsis is an important cause of mortality. Optimal sepsis management including fluid resuscitation, early antibiotic administration, and patient monitoring is limited by lack of supplies and skilled health workers.
OBJECTIVE:To evaluate whether early, monitored sepsis management provided by a study medical officer can improve survival among patients with severe sepsis admitted to two public hospitals in Uganda.
DESIGN, SETTING, AND PATIENTS:A prospective before and after study of an intervention cohort (n = 426) with severe sepsis receiving early, monitored sepsis management compared to an observation cohort (n = 245) of similarly ill patients with severe sepsis receiving standard management after admission to the medical wards of two Ugandan hospitals.
INTERVENTION:Early sepsis management provided by a dedicated study medical officer comprising fluid resuscitation, early antibiotics, and regular monitoring in the first 6 hrs of hospitalization.
MEASUREMENTS:Kaplan-Meier survival and unadjusted and adjusted Cox proportional hazards analysis were used to compare the effect of early, monitored sepsis management on 30-day mortality between the intervention cohort (enrolled May 2008 to May 2009) and observation cohort (enrolled July 2006 to November 2006).
RESULTS:The majority (86%) of patients in both cohorts were human immuno-deficiency virus-infected. Median fluid volume provided in the first 6 hrs of hospitalization was higher in intervention than observation cohort patients (3000 mL vs. 500 mL, p < .001) and a greater proportion of intervention cohort patients received antibacterial therapy in <1 hr (67% vs. 30.4%, p < .001). Mortality at 30 days was significantly lower in the intervention cohort compared to the observation cohort (33.0% vs. 45.7%, log-rank p = .005). After adjustment for potential confounders, the hazard of 30-day mortality was 26% less in the intervention cohort compared to the observation cohort (adjusted hazards ratio 0.74, 95% confidence interval 0.55–0.98). Mortality among the 13% of intervention patients who developed signs of respiratory distress was associated with baseline illness severity rather than fluid volume administered.
CONCLUSION:Early, monitored management of severely septic patients in Uganda improves survival and is feasible and safe even in a busy public referral hospital.</description><identifier>ISSN: 0090-3493</identifier><identifier>EISSN: 1530-0293</identifier><identifier>DOI: 10.1097/CCM.0b013e31824e65d7</identifier><identifier>PMID: 22564958</identifier><identifier>CODEN: CCMDC7</identifier><language>eng</language><publisher>Hagerstown, MD: by the Society of Critical Care Medicine and Lippincott Williams & Wilkins</publisher><subject>Adult ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Anti-Bacterial Agents - therapeutic use ; Biological and medical sciences ; Blood Pressure ; Emergency and intensive care: infection, septic shock ; Female ; Fluid Therapy - statistics & numerical data ; HIV Infections - epidemiology ; Hospitalization ; Humans ; Intensive care medicine ; Kaplan-Meier Estimate ; Male ; Medical sciences ; Monitoring, Physiologic ; Proportional Hazards Models ; Prospective Studies ; Respiratory Distress Syndrome, Adult - mortality ; Sepsis - mortality ; Sepsis - therapy ; Severity of Illness Index ; Uganda - epidemiology</subject><ispartof>Critical care medicine, 2012-07, Vol.40 (7), p.2050-2058</ispartof><rights>2012 by the Society of Critical Care Medicine and Lippincott Williams & Wilkins</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c5266-1750f4b585e77d9c0b04bdf6844045a2ec9cc611b9e91d8b9c94bae7b031dfb23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26074232$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22564958$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jacob, Shevin T</creatorcontrib><creatorcontrib>Banura, Patrick</creatorcontrib><creatorcontrib>Baeten, Jared M</creatorcontrib><creatorcontrib>Moore, Christopher C</creatorcontrib><creatorcontrib>Meya, David</creatorcontrib><creatorcontrib>Nakiyingi, Lydia</creatorcontrib><creatorcontrib>Burke, Rebecca</creatorcontrib><creatorcontrib>Horton, Cheryl Lynn</creatorcontrib><creatorcontrib>Iga, Boaz</creatorcontrib><creatorcontrib>Wald, Anna</creatorcontrib><creatorcontrib>Reynolds, Steven J</creatorcontrib><creatorcontrib>Mayanja-Kizza, Harriet</creatorcontrib><creatorcontrib>Scheld, W Michael</creatorcontrib><creatorcontrib>Promoting Resource-Limited Interventions for Sepsis Management in Uganda Study Group</creatorcontrib><title>The impact of early monitored management on survival in hospitalized adult Ugandan patients with severe sepsis: A prospective intervention study</title><title>Critical care medicine</title><addtitle>Crit Care Med</addtitle><description>In sub-Saharan Africa, sepsis is an important cause of mortality. Optimal sepsis management including fluid resuscitation, early antibiotic administration, and patient monitoring is limited by lack of supplies and skilled health workers.
OBJECTIVE:To evaluate whether early, monitored sepsis management provided by a study medical officer can improve survival among patients with severe sepsis admitted to two public hospitals in Uganda.
DESIGN, SETTING, AND PATIENTS:A prospective before and after study of an intervention cohort (n = 426) with severe sepsis receiving early, monitored sepsis management compared to an observation cohort (n = 245) of similarly ill patients with severe sepsis receiving standard management after admission to the medical wards of two Ugandan hospitals.
INTERVENTION:Early sepsis management provided by a dedicated study medical officer comprising fluid resuscitation, early antibiotics, and regular monitoring in the first 6 hrs of hospitalization.
MEASUREMENTS:Kaplan-Meier survival and unadjusted and adjusted Cox proportional hazards analysis were used to compare the effect of early, monitored sepsis management on 30-day mortality between the intervention cohort (enrolled May 2008 to May 2009) and observation cohort (enrolled July 2006 to November 2006).
RESULTS:The majority (86%) of patients in both cohorts were human immuno-deficiency virus-infected. Median fluid volume provided in the first 6 hrs of hospitalization was higher in intervention than observation cohort patients (3000 mL vs. 500 mL, p < .001) and a greater proportion of intervention cohort patients received antibacterial therapy in <1 hr (67% vs. 30.4%, p < .001). Mortality at 30 days was significantly lower in the intervention cohort compared to the observation cohort (33.0% vs. 45.7%, log-rank p = .005). After adjustment for potential confounders, the hazard of 30-day mortality was 26% less in the intervention cohort compared to the observation cohort (adjusted hazards ratio 0.74, 95% confidence interval 0.55–0.98). Mortality among the 13% of intervention patients who developed signs of respiratory distress was associated with baseline illness severity rather than fluid volume administered.
CONCLUSION:Early, monitored management of severely septic patients in Uganda improves survival and is feasible and safe even in a busy public referral hospital.</description><subject>Adult</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure</subject><subject>Emergency and intensive care: infection, septic shock</subject><subject>Female</subject><subject>Fluid Therapy - statistics & numerical data</subject><subject>HIV Infections - epidemiology</subject><subject>Hospitalization</subject><subject>Humans</subject><subject>Intensive care medicine</subject><subject>Kaplan-Meier Estimate</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Monitoring, Physiologic</subject><subject>Proportional Hazards Models</subject><subject>Prospective Studies</subject><subject>Respiratory Distress Syndrome, Adult - mortality</subject><subject>Sepsis - mortality</subject><subject>Sepsis - therapy</subject><subject>Severity of Illness Index</subject><subject>Uganda - epidemiology</subject><issn>0090-3493</issn><issn>1530-0293</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkdtu1DAQhi0EomXhDRDyDVJvUnxKHHOBVK04SUXctNeW40w2BueA7WS1PAWPjFddWsA3I3u-f2Y8P0IvKbmkRMk32-2XS9IQyoHTmgmoylY-Que05KQgTPHH6JwQRQouFD9Dz2L8RggVpeRP0RljZSVUWZ-jXzc9YDfMxiY8dRhM8Ac8TKNLU4AWD2Y0OxhgzNkRxyWsbjUeuxH3U5xdMt79zJhpF5_w7c6MrRnxbJLLioj3LvU4wgoBcpiji2_xFZ5DloJNbs2dxwRhzbA7lk9Le3iOnnTGR3hxiht0--H9zfZTcf314-ft1XVhS1ZVBZUl6URT1iVI2SqbNyGatqtqIYgoDQOrrK0obRQo2taNsko0BmRDOG27hvENendXd16aAVqbZwjG6zm4wYSDnozT_2ZG1-vdtGrOZS3zGjfo4lQgTD8WiEkPLlrw3owwLVFTwnnJOeMqo-IOtfnrMUB334YSfTRTZzP1_2Zm2au_R7wX_XEvA69PgInW-C6Y0br4wFVECsbZQ__95PO-43e_7CHoHoxPvSb5cCaqghHKiMy34vhU8d9pA71h</recordid><startdate>201207</startdate><enddate>201207</enddate><creator>Jacob, Shevin T</creator><creator>Banura, Patrick</creator><creator>Baeten, Jared M</creator><creator>Moore, Christopher C</creator><creator>Meya, David</creator><creator>Nakiyingi, Lydia</creator><creator>Burke, Rebecca</creator><creator>Horton, Cheryl Lynn</creator><creator>Iga, Boaz</creator><creator>Wald, Anna</creator><creator>Reynolds, Steven J</creator><creator>Mayanja-Kizza, Harriet</creator><creator>Scheld, W Michael</creator><general>by the Society of Critical Care Medicine and Lippincott Williams & Wilkins</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201207</creationdate><title>The impact of early monitored management on survival in hospitalized adult Ugandan patients with severe sepsis: A prospective intervention study</title><author>Jacob, Shevin T ; Banura, Patrick ; Baeten, Jared M ; Moore, Christopher C ; Meya, David ; Nakiyingi, Lydia ; Burke, Rebecca ; Horton, Cheryl Lynn ; Iga, Boaz ; Wald, Anna ; Reynolds, Steven J ; Mayanja-Kizza, Harriet ; Scheld, W Michael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5266-1750f4b585e77d9c0b04bdf6844045a2ec9cc611b9e91d8b9c94bae7b031dfb23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure</topic><topic>Emergency and intensive care: infection, septic shock</topic><topic>Female</topic><topic>Fluid Therapy - statistics & numerical data</topic><topic>HIV Infections - epidemiology</topic><topic>Hospitalization</topic><topic>Humans</topic><topic>Intensive care medicine</topic><topic>Kaplan-Meier Estimate</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Monitoring, Physiologic</topic><topic>Proportional Hazards Models</topic><topic>Prospective Studies</topic><topic>Respiratory Distress Syndrome, Adult - mortality</topic><topic>Sepsis - mortality</topic><topic>Sepsis - therapy</topic><topic>Severity of Illness Index</topic><topic>Uganda - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jacob, Shevin T</creatorcontrib><creatorcontrib>Banura, Patrick</creatorcontrib><creatorcontrib>Baeten, Jared M</creatorcontrib><creatorcontrib>Moore, Christopher C</creatorcontrib><creatorcontrib>Meya, David</creatorcontrib><creatorcontrib>Nakiyingi, Lydia</creatorcontrib><creatorcontrib>Burke, Rebecca</creatorcontrib><creatorcontrib>Horton, Cheryl Lynn</creatorcontrib><creatorcontrib>Iga, Boaz</creatorcontrib><creatorcontrib>Wald, Anna</creatorcontrib><creatorcontrib>Reynolds, Steven J</creatorcontrib><creatorcontrib>Mayanja-Kizza, Harriet</creatorcontrib><creatorcontrib>Scheld, W Michael</creatorcontrib><creatorcontrib>Promoting Resource-Limited Interventions for Sepsis Management in Uganda Study Group</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Critical care medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jacob, Shevin T</au><au>Banura, Patrick</au><au>Baeten, Jared M</au><au>Moore, Christopher C</au><au>Meya, David</au><au>Nakiyingi, Lydia</au><au>Burke, Rebecca</au><au>Horton, Cheryl Lynn</au><au>Iga, Boaz</au><au>Wald, Anna</au><au>Reynolds, Steven J</au><au>Mayanja-Kizza, Harriet</au><au>Scheld, W Michael</au><aucorp>Promoting Resource-Limited Interventions for Sepsis Management in Uganda Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The impact of early monitored management on survival in hospitalized adult Ugandan patients with severe sepsis: A prospective intervention study</atitle><jtitle>Critical care medicine</jtitle><addtitle>Crit Care Med</addtitle><date>2012-07</date><risdate>2012</risdate><volume>40</volume><issue>7</issue><spage>2050</spage><epage>2058</epage><pages>2050-2058</pages><issn>0090-3493</issn><eissn>1530-0293</eissn><coden>CCMDC7</coden><abstract>In sub-Saharan Africa, sepsis is an important cause of mortality. Optimal sepsis management including fluid resuscitation, early antibiotic administration, and patient monitoring is limited by lack of supplies and skilled health workers.
OBJECTIVE:To evaluate whether early, monitored sepsis management provided by a study medical officer can improve survival among patients with severe sepsis admitted to two public hospitals in Uganda.
DESIGN, SETTING, AND PATIENTS:A prospective before and after study of an intervention cohort (n = 426) with severe sepsis receiving early, monitored sepsis management compared to an observation cohort (n = 245) of similarly ill patients with severe sepsis receiving standard management after admission to the medical wards of two Ugandan hospitals.
INTERVENTION:Early sepsis management provided by a dedicated study medical officer comprising fluid resuscitation, early antibiotics, and regular monitoring in the first 6 hrs of hospitalization.
MEASUREMENTS:Kaplan-Meier survival and unadjusted and adjusted Cox proportional hazards analysis were used to compare the effect of early, monitored sepsis management on 30-day mortality between the intervention cohort (enrolled May 2008 to May 2009) and observation cohort (enrolled July 2006 to November 2006).
RESULTS:The majority (86%) of patients in both cohorts were human immuno-deficiency virus-infected. Median fluid volume provided in the first 6 hrs of hospitalization was higher in intervention than observation cohort patients (3000 mL vs. 500 mL, p < .001) and a greater proportion of intervention cohort patients received antibacterial therapy in <1 hr (67% vs. 30.4%, p < .001). Mortality at 30 days was significantly lower in the intervention cohort compared to the observation cohort (33.0% vs. 45.7%, log-rank p = .005). After adjustment for potential confounders, the hazard of 30-day mortality was 26% less in the intervention cohort compared to the observation cohort (adjusted hazards ratio 0.74, 95% confidence interval 0.55–0.98). Mortality among the 13% of intervention patients who developed signs of respiratory distress was associated with baseline illness severity rather than fluid volume administered.
CONCLUSION:Early, monitored management of severely septic patients in Uganda improves survival and is feasible and safe even in a busy public referral hospital.</abstract><cop>Hagerstown, MD</cop><pub>by the Society of Critical Care Medicine and Lippincott Williams & Wilkins</pub><pmid>22564958</pmid><doi>10.1097/CCM.0b013e31824e65d7</doi><tpages>9</tpages></addata></record> |
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| ispartof | Critical care medicine, 2012-07, Vol.40 (7), p.2050-2058 |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adult Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Anti-Bacterial Agents - therapeutic use Biological and medical sciences Blood Pressure Emergency and intensive care: infection, septic shock Female Fluid Therapy - statistics & numerical data HIV Infections - epidemiology Hospitalization Humans Intensive care medicine Kaplan-Meier Estimate Male Medical sciences Monitoring, Physiologic Proportional Hazards Models Prospective Studies Respiratory Distress Syndrome, Adult - mortality Sepsis - mortality Sepsis - therapy Severity of Illness Index Uganda - epidemiology |
| title | The impact of early monitored management on survival in hospitalized adult Ugandan patients with severe sepsis: A prospective intervention study |
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