High frequency of HIV mutations associated with HLA-C suggests enhanced HLA-C-restricted CTL selective pressure associated with an AIDS-protective polymorphism

Delayed HIV-1 disease progression is associated with a single nucleotide polymorphism upstream of the HLA-C gene that correlates with differential expression of the HLA-C Ag. This polymorphism was recently shown to be a marker for a protective variant in the 3'UTR of HLA-C that disrupts a micro...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of immunology (1950) 2012-05, Vol.188 (9), p.4663-4670
Hauptverfasser:	Blais, Marie-Eve, Zhang, Yonghong, Rostron, Tim, Griffin, Harry, Taylor, Stephen, Xu, Keyi, Yan, Huiping, Wu, Hao, James, Ian, John, Mina, Dong, Tao, Rowland-Jones, Sarah L
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions - genetics 3' Untranslated Regions - immunology Acquired Immunodeficiency Syndrome - epidemiology Acquired Immunodeficiency Syndrome - genetics Acquired Immunodeficiency Syndrome - immunology Acquired Immunodeficiency Syndrome - metabolism Alleles Asian Continental Ancestry Group CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism China - epidemiology DNA, Viral - genetics DNA, Viral - immunology DNA, Viral - metabolism Female Gene Expression Regulation - genetics Gene Expression Regulation - immunology HIV-1 - genetics HIV-1 - immunology HIV-1 - metabolism HLA-C Antigens - biosynthesis HLA-C Antigens - genetics HLA-C Antigens - immunology Human immunodeficiency virus 1 Humans Interferon-gamma - genetics Interferon-gamma - immunology Interferon-gamma - metabolism Male Mutation Polymorphism, Genetic Proviruses - genetics Proviruses - immunology Proviruses - metabolism Retrospective Studies
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!