Delineation of Joint Molecule Resolution Pathways in Meiosis Identifies a Crossover-Specific Resolvase

At the final step of homologous recombination, Holliday junction-containing joint molecules (JMs) are resolved to form crossover or noncrossover products. The enzymes responsible for JM resolution in vivo remain uncertain, but three distinct endonucleases capable of resolving JMs in vitro have been...

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Veröffentlicht in:	Cell 2012-04, Vol.149 (2), p.334-347
Hauptverfasser:	Zakharyevich, Kseniya, Tang, Shangming, Ma, Yunmei, Hunter, Neil
Format:	Artikel
Sprache:	eng
Schlagworte:	crossing over Crossing Over, Genetic DNA, Cruciform Endodeoxyribonucleases - genetics Endodeoxyribonucleases - metabolism enzymes Holliday Junction Resolvases - metabolism homologous recombination mammals Meiosis monitoring mutants Mutation RecQ Helicases - genetics RecQ Helicases - metabolism Saccharomyces cerevisiae Saccharomyces cerevisiae - cytology Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism yeasts
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