Insulin biosynthesis in neuronal progenitors derived from adult hippocampus and the olfactory bulb
In the present study, we demonstrated that insulin is produced not only in the mammalian pancreas but also in adult neuronal cells derived from the hippocampus and olfactory bulb (OB). Paracrine Wnt3 plays an essential role in promoting the active expression of insulin in both hippocampal and OB‐der...
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| Veröffentlicht in: | EMBO molecular medicine 2011-12, Vol.3 (12), p.742-754 |
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| creator | Kuwabara, Tomoko Kagalwala, Mohamedi N. Onuma, Yasuko Ito, Yuzuru Warashina, Masaki Terashima, Kazuyuki Sanosaka, Tsukasa Nakashima, Kinichi Gage, Fred H. Asashima, Makoto |
| description | In the present study, we demonstrated that insulin is produced not only in the mammalian pancreas but also in adult neuronal cells derived from the hippocampus and olfactory bulb (OB). Paracrine Wnt3 plays an essential role in promoting the active expression of insulin in both hippocampal and OB‐derived neural stem cells. Our analysis indicated that the balance between Wnt3, which triggers the expression of insulin via NeuroD1, and IGFBP‐4, which inhibits the original Wnt3 action, is regulated depending on diabetic (DB) status. We also show that adult neural progenitors derived from DB animals retain the ability to give rise to insulin‐producing cells and that grafting neuronal progenitors into the pancreas of DB animals reduces glucose levels. This study provides an example of a simple and direct use of adult stem cells from one organ to another, without introducing additional inductive genes.
See accompanying article
http://dx.doi.org/10.1002/emmm.201100178 |
| doi_str_mv | 10.1002/emmm.201100177 |
| format | Article |
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See accompanying article
http://dx.doi.org/10.1002/emmm.201100178</description><identifier>ISSN: 1757-4676</identifier><identifier>EISSN: 1757-4684</identifier><identifier>DOI: 10.1002/emmm.201100177</identifier><identifier>PMID: 21984534</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Animals ; Beta2 protein ; Biosynthesis ; Diabetes ; Diabetes mellitus ; Experiments ; Female ; Gene expression ; Gene Expression Profiling ; Hippocampus ; Hippocampus - cytology ; Insulin ; Insulin - biosynthesis ; Insulin resistance ; Mammals ; Mice ; Mice, Inbred C57BL ; neural stem cell ; Neural stem cells ; Neural Stem Cells - metabolism ; Neurogenesis ; Neurons ; Olfactory bulb ; Olfactory Bulb - cytology ; Pancreas ; Pancreas transplantation ; Paracrine signalling ; Rats ; Research Article ; Stem cell transplantation ; Stem cells ; Transcription factors</subject><ispartof>EMBO molecular medicine, 2011-12, Vol.3 (12), p.742-754</ispartof><rights>EMBO Molecular Medicine 2011</rights><rights>Copyright © 2011 EMBO Molecular Medicine</rights><rights>Copyright © 2011 EMBO Molecular Medicine.</rights><rights>Copyright John Wiley & Sons, Inc. Dec 2011</rights><rights>Copyright © 2011 EMBO Molecular Medicine 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5077-986168fd6cf4c0d6a7f4a4f5adbfa814e691d0d5a6e32e0a27ee6e72a87d09df3</citedby><cites>FETCH-LOGICAL-c5077-986168fd6cf4c0d6a7f4a4f5adbfa814e691d0d5a6e32e0a27ee6e72a87d09df3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377118/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377118/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,1417,11561,27923,27924,45573,45574,46051,46475,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21984534$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kuwabara, Tomoko</creatorcontrib><creatorcontrib>Kagalwala, Mohamedi N.</creatorcontrib><creatorcontrib>Onuma, Yasuko</creatorcontrib><creatorcontrib>Ito, Yuzuru</creatorcontrib><creatorcontrib>Warashina, Masaki</creatorcontrib><creatorcontrib>Terashima, Kazuyuki</creatorcontrib><creatorcontrib>Sanosaka, Tsukasa</creatorcontrib><creatorcontrib>Nakashima, Kinichi</creatorcontrib><creatorcontrib>Gage, Fred H.</creatorcontrib><creatorcontrib>Asashima, Makoto</creatorcontrib><title>Insulin biosynthesis in neuronal progenitors derived from adult hippocampus and the olfactory bulb</title><title>EMBO molecular medicine</title><addtitle>EMBO Mol Med</addtitle><addtitle>EMBO Mol Med</addtitle><description>In the present study, we demonstrated that insulin is produced not only in the mammalian pancreas but also in adult neuronal cells derived from the hippocampus and olfactory bulb (OB). Paracrine Wnt3 plays an essential role in promoting the active expression of insulin in both hippocampal and OB‐derived neural stem cells. Our analysis indicated that the balance between Wnt3, which triggers the expression of insulin via NeuroD1, and IGFBP‐4, which inhibits the original Wnt3 action, is regulated depending on diabetic (DB) status. We also show that adult neural progenitors derived from DB animals retain the ability to give rise to insulin‐producing cells and that grafting neuronal progenitors into the pancreas of DB animals reduces glucose levels. This study provides an example of a simple and direct use of adult stem cells from one organ to another, without introducing additional inductive genes.
See accompanying article
http://dx.doi.org/10.1002/emmm.201100178</description><subject>Animals</subject><subject>Beta2 protein</subject><subject>Biosynthesis</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Experiments</subject><subject>Female</subject><subject>Gene expression</subject><subject>Gene Expression Profiling</subject><subject>Hippocampus</subject><subject>Hippocampus - cytology</subject><subject>Insulin</subject><subject>Insulin - biosynthesis</subject><subject>Insulin resistance</subject><subject>Mammals</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>neural stem cell</subject><subject>Neural stem cells</subject><subject>Neural Stem Cells - metabolism</subject><subject>Neurogenesis</subject><subject>Neurons</subject><subject>Olfactory bulb</subject><subject>Olfactory Bulb - cytology</subject><subject>Pancreas</subject><subject>Pancreas transplantation</subject><subject>Paracrine signalling</subject><subject>Rats</subject><subject>Research Article</subject><subject>Stem cell transplantation</subject><subject>Stem cells</subject><subject>Transcription factors</subject><issn>1757-4676</issn><issn>1757-4684</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkc9vFCEcxYnR2B969WhIPHjaLTAzwFxMTFNrk2686Jkww5ddGgZGGGr2v5dm61pNjBfgGz7v5cFD6A0la0oIu4BpmtaM0DpQIZ6hUyo6sWq5bJ8fz4KfoLOc7wjhHafyJTphtJdt17SnaLgJuXgX8OBi3odlB9llXOcAJcWgPZ5T3EJwS0wZG0juHgy2KU5Ym-IXvHPzHEc9zSVjHQyuDjh6q8cq2OOh-OEVemG1z_D6cT9H3z5dfb38vLr9cn1z-fF2NXZEiFUvOeXSGj7adiSGa2Fb3dpOm8FqSVvgPTXEdJpDw4BoJgA4CKalMKQ3tjlHHw6-cxkmMCOEJWmv5uQmnfYqaqf-vAlup7bxXjWNEJTKavD-0SDF7wXyoiaXR_BeB4glq55IQpu6VPLdX-RdLKn-VlaM9T1ltBOsUusDNaaYcwJ7zEKJemhPPbSnju1VwdunLzjiv-qqQH8AfjgP-__YqavNZvPU_OKgzVUWtpB-Z_5HnJ9MJrmL</recordid><startdate>20111201</startdate><enddate>20111201</enddate><creator>Kuwabara, Tomoko</creator><creator>Kagalwala, Mohamedi N.</creator><creator>Onuma, Yasuko</creator><creator>Ito, Yuzuru</creator><creator>Warashina, Masaki</creator><creator>Terashima, Kazuyuki</creator><creator>Sanosaka, Tsukasa</creator><creator>Nakashima, Kinichi</creator><creator>Gage, Fred H.</creator><creator>Asashima, Makoto</creator><general>Nature Publishing Group UK</general><general>WILEY‐VCH Verlag</general><general>EMBO Press</general><general>WILEY-VCH Verlag</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20111201</creationdate><title>Insulin biosynthesis in neuronal progenitors derived from adult hippocampus and the olfactory bulb</title><author>Kuwabara, Tomoko ; Kagalwala, Mohamedi N. ; Onuma, Yasuko ; Ito, Yuzuru ; Warashina, Masaki ; Terashima, Kazuyuki ; Sanosaka, Tsukasa ; Nakashima, Kinichi ; Gage, Fred H. ; Asashima, Makoto</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5077-986168fd6cf4c0d6a7f4a4f5adbfa814e691d0d5a6e32e0a27ee6e72a87d09df3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animals</topic><topic>Beta2 protein</topic><topic>Biosynthesis</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Experiments</topic><topic>Female</topic><topic>Gene expression</topic><topic>Gene Expression Profiling</topic><topic>Hippocampus</topic><topic>Hippocampus - cytology</topic><topic>Insulin</topic><topic>Insulin - biosynthesis</topic><topic>Insulin resistance</topic><topic>Mammals</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>neural stem cell</topic><topic>Neural stem cells</topic><topic>Neural Stem Cells - metabolism</topic><topic>Neurogenesis</topic><topic>Neurons</topic><topic>Olfactory bulb</topic><topic>Olfactory Bulb - cytology</topic><topic>Pancreas</topic><topic>Pancreas transplantation</topic><topic>Paracrine signalling</topic><topic>Rats</topic><topic>Research Article</topic><topic>Stem cell transplantation</topic><topic>Stem cells</topic><topic>Transcription factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kuwabara, Tomoko</creatorcontrib><creatorcontrib>Kagalwala, Mohamedi N.</creatorcontrib><creatorcontrib>Onuma, Yasuko</creatorcontrib><creatorcontrib>Ito, Yuzuru</creatorcontrib><creatorcontrib>Warashina, Masaki</creatorcontrib><creatorcontrib>Terashima, Kazuyuki</creatorcontrib><creatorcontrib>Sanosaka, Tsukasa</creatorcontrib><creatorcontrib>Nakashima, Kinichi</creatorcontrib><creatorcontrib>Gage, Fred H.</creatorcontrib><creatorcontrib>Asashima, Makoto</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Wiley Free Content</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>EMBO molecular medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kuwabara, Tomoko</au><au>Kagalwala, Mohamedi N.</au><au>Onuma, Yasuko</au><au>Ito, Yuzuru</au><au>Warashina, Masaki</au><au>Terashima, Kazuyuki</au><au>Sanosaka, Tsukasa</au><au>Nakashima, Kinichi</au><au>Gage, Fred H.</au><au>Asashima, Makoto</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Insulin biosynthesis in neuronal progenitors derived from adult hippocampus and the olfactory bulb</atitle><jtitle>EMBO molecular medicine</jtitle><stitle>EMBO Mol Med</stitle><addtitle>EMBO Mol Med</addtitle><date>2011-12-01</date><risdate>2011</risdate><volume>3</volume><issue>12</issue><spage>742</spage><epage>754</epage><pages>742-754</pages><issn>1757-4676</issn><eissn>1757-4684</eissn><abstract>In the present study, we demonstrated that insulin is produced not only in the mammalian pancreas but also in adult neuronal cells derived from the hippocampus and olfactory bulb (OB). Paracrine Wnt3 plays an essential role in promoting the active expression of insulin in both hippocampal and OB‐derived neural stem cells. Our analysis indicated that the balance between Wnt3, which triggers the expression of insulin via NeuroD1, and IGFBP‐4, which inhibits the original Wnt3 action, is regulated depending on diabetic (DB) status. We also show that adult neural progenitors derived from DB animals retain the ability to give rise to insulin‐producing cells and that grafting neuronal progenitors into the pancreas of DB animals reduces glucose levels. This study provides an example of a simple and direct use of adult stem cells from one organ to another, without introducing additional inductive genes.
See accompanying article
http://dx.doi.org/10.1002/emmm.201100178</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>21984534</pmid><doi>10.1002/emmm.201100177</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Beta2 protein Biosynthesis Diabetes Diabetes mellitus Experiments Female Gene expression Gene Expression Profiling Hippocampus Hippocampus - cytology Insulin Insulin - biosynthesis Insulin resistance Mammals Mice Mice, Inbred C57BL neural stem cell Neural stem cells Neural Stem Cells - metabolism Neurogenesis Neurons Olfactory bulb Olfactory Bulb - cytology Pancreas Pancreas transplantation Paracrine signalling Rats Research Article Stem cell transplantation Stem cells Transcription factors |
| title | Insulin biosynthesis in neuronal progenitors derived from adult hippocampus and the olfactory bulb |
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