Apples to origins: identifying brain tumor stem cell genes by comparing transcriptomes of normal and cancer stem cells

Apples to origins: identifying brain tumor stem cell genes by comparing transcriptomes of normal and cancer stem cells

The mechanisms whereby medulloblastoma stem cells coordinate tumor propagation are poorly understood. Using microarray analysis, Corno and colleagues draw parallels and distinctions between medulloblastoma stem cells from the Ptch(+/-) mouse and normal neural stem cells, identifying Ebf3 as a cancer...

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Veröffentlicht in:Cancer discovery 2012-06, Vol.2 (6), p.492-494
Hauptverfasser: Wortham, Matthew, Yan, Hai
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Cerebellar Neoplasms - genetics
Gene Expression Profiling
Humans
Medulloblastoma - genetics
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Zusammenfassung:The mechanisms whereby medulloblastoma stem cells coordinate tumor propagation are poorly understood. Using microarray analysis, Corno and colleagues draw parallels and distinctions between medulloblastoma stem cells from the Ptch(+/-) mouse and normal neural stem cells, identifying Ebf3 as a cancer stem cell-specific transcript critical for tumor growth.
ISSN:2159-8274
2159-8290
DOI:10.1158/2159-8290.CD-12-0182