Alpha- and beta-secretase activity as a function of age and beta-amyloid in Down syndrome and normal brain

Abstract Aged individuals with Down syndrome (DS) develop Alzheimer's disease (AD) neuropathology by the age of 40 years. The purpose of the current study was to measure age-associated changes in APP processing in 36 individuals with DS (5 months–69 years) and in 26 controls (5 months–100 years...

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Veröffentlicht in:	Neurobiology of aging 2007-10, Vol.28 (10), p.1493-1506
Hauptverfasser:	Nistor, M, Don, M, Parekh, M, Sarsoza, F, Goodus, M, Lopez, G.E, Kawas, C, Leverenz, J, Doran, E, Lott, I.T, Hill, M, Head, E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aging - metabolism Aging - pathology Alzheimer's disease Amyloid beta-Peptides - biosynthesis Amyloid beta-Protein Precursor - metabolism Amyloid Precursor Protein Secretases - metabolism Beta-amyloid Biomarkers - metabolism Brain - enzymology Brain - pathology Brain - physiopathology Child Child, Preschool Disease Progression Down Syndrome - enzymology Down Syndrome - pathology Down Syndrome - physiopathology Female Humans Infant Internal Medicine Male Middle Aged Neurology Oldest old Plaque, Amyloid - enzymology Plaque, Amyloid - pathology Reference Values Trisomy 21 Up-Regulation - physiology
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