G Proteins and Autocrine Signaling Differentially Regulate Gonadotropin Subunit Expression in Pituitary Gonadotrope

Gonadotropin-releasing hormone (GnRH) acts at gonadotropes to direct the synthesis of the gonadotropins, follicle-stimulating hormone (FSH), and luteinizing hormone (LH). The frequency of GnRH pulses determines the pattern of gonadotropin synthesis. Several hypotheses for how the gonadotrope decodes...

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Veröffentlicht in:	The Journal of biological chemistry 2012-06, Vol.287 (25), p.21550-21560
Hauptverfasser:	Choi, Soon-Gang, Jia, Jingjing, Pfeffer, Robert L., Sealfon, Stuart C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autocrine Autocrine Communication - physiology Cell Line Cell Signaling Follicle Stimulating Hormone - genetics Follicle Stimulating Hormone - metabolism G Protein-coupled Receptors (GPCRs) G Proteins Gene Expression Regulation - physiology Gene Regulation Gonadotrope Gonadotropin Gonadotropin-Releasing Hormone Gonadotropins - genetics Gonadotropins - metabolism GTP-Binding Proteins - genetics GTP-Binding Proteins - metabolism Luteinizing Hormone - genetics Luteinizing Hormone - metabolism Mice Paracrine Pituitary Gland - metabolism Signaling Circuit siRNA
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