Increased cortical expression of FK506 binding protein-51 in HIV-associated neurocognitive disorders

FK506 binding protein (FKBP)-51 and FKBP52 act as molecular chaperones to control glucocorticoid receptor (GR) sensitivity. Dysregulation of proteins involved in GR-mediated signaling can lead to maladaptive stress response and aging-related cognitive decline. As HIV infection is related to chronic...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of neurovirology 2012-08, Vol.18 (4), p.313-322
Hauptverfasser:	Soontornniyomkij, Virawudh, Everall, Ian P., Moore, David J., Gouaux, Ben, Tatro, Erick T., Gospodarev, Vadim, Masliah, Eliezer, Yin, Nicole S., Vinters, Harry V., Achim, Cristian L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult AIDS Dementia Complex - complications AIDS Dementia Complex - drug therapy AIDS Dementia Complex - genetics AIDS Dementia Complex - metabolism Anatomy Anti-Retroviral Agents - administration & dosage Anti-Retroviral Agents - therapeutic use Antiviral agents Biomedical and Life Sciences Biomedicine Case-Control Studies Chaperones Chronic infection Cognition Cognitive ability Cortex Feedback Female Gene Expression Glucocorticoid receptors Hand Hepacivirus - physiology Hepatitis C virus Hepatitis C, Chronic - complications Hepatitis C, Chronic - drug therapy Hepatitis C, Chronic - genetics Hepatitis C, Chronic - metabolism Human immunodeficiency virus Humans Immunohistochemistry Immunology Infectious Diseases Male Methamphetamine Methamphetamine - administration & dosage Methamphetamine - adverse effects Middle Aged Neurology Neurosciences Parahippocampal Gyrus - metabolism Parahippocampal Gyrus - pathology Parahippocampal Gyrus - virology Signal Transduction - genetics Stress Stress, Physiological - genetics Substance-Related Disorders - complications Substance-Related Disorders - genetics Substance-Related Disorders - metabolism Substantia alba Tacrolimus Tacrolimus Binding Proteins - genetics Tacrolimus Binding Proteins - metabolism Tacrolimus-binding protein Virology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!