High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq

Hypoxia-inducible factor (HIF) regulates the major transcriptional cascade central to the response of all mammalian cells to alterations in oxygen tension. Expression arrays indicate that many hundreds of genes are regulated by this pathway, controlling diverse processes that in turn orchestrate bot...

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Veröffentlicht in:	Blood 2011-06, Vol.117 (23), p.e207-e217
Hauptverfasser:	Schödel, Johannes, Oikonomopoulos, Spyros, Ragoussis, Jiannis, Pugh, Christopher W., Ratcliffe, Peter J., Mole, David R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Basic Helix-Loop-Helix Transcription Factors - genetics Basic Helix-Loop-Helix Transcription Factors - metabolism Cell Line, Tumor Chromatin Immunoprecipitation - methods Chromosome Mapping Epigenesis, Genetic - physiology Female Genome, Human - physiology Genome-Wide Association Study Humans Oxygen - metabolism Red Cells, Iron, and Erythropoiesis Response Elements - physiology Vascular Biology
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