Pulmonary Complications of Sickle Cell Disease
Sickle cell disease (SCD) is a common monogenetic disorder with high associated morbidity and mortality. The pulmonary complications of SCD are of particular importance, as acute chest syndrome and pulmonary hypertension have the highest associated mortality rates within this population. This articl...
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| Veröffentlicht in: | American journal of respiratory and critical care medicine 2012-06, Vol.185 (11), p.1154-1165 |
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| container_title | American journal of respiratory and critical care medicine |
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| creator | MILLER, Andrew C GLADWIN, Mark T |
| description | Sickle cell disease (SCD) is a common monogenetic disorder with high associated morbidity and mortality. The pulmonary complications of SCD are of particular importance, as acute chest syndrome and pulmonary hypertension have the highest associated mortality rates within this population. This article reviews the pathophysiology, diagnosis, and treatment of clinically significant pulmonary manifestations of SCD, including acute chest syndrome, asthma, and pulmonary hypertension in adult and pediatric patients. Clinicians should be vigilant in screening and treating such comorbidities to improve patient outcomes. |
| doi_str_mv | 10.1164/rccm.201111-2082ci |
| format | Article |
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The pulmonary complications of SCD are of particular importance, as acute chest syndrome and pulmonary hypertension have the highest associated mortality rates within this population. This article reviews the pathophysiology, diagnosis, and treatment of clinically significant pulmonary manifestations of SCD, including acute chest syndrome, asthma, and pulmonary hypertension in adult and pediatric patients. Clinicians should be vigilant in screening and treating such comorbidities to improve patient outcomes.</description><identifier>ISSN: 1073-449X</identifier><identifier>EISSN: 1535-4970</identifier><identifier>DOI: 10.1164/rccm.201111-2082ci</identifier><identifier>PMID: 22447965</identifier><language>eng</language><publisher>New York, NY: American Thoracic Society</publisher><subject>Acute Chest Syndrome - diagnostic imaging ; Acute Chest Syndrome - epidemiology ; Acute Chest Syndrome - therapy ; Adolescent ; Adult ; Adults ; Anemia ; Anemia, Sickle Cell - diagnosis ; Anemia, Sickle Cell - epidemiology ; Anemia, Sickle Cell - therapy ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Asthma ; Asthma - diagnostic imaging ; Asthma - epidemiology ; Asthma - therapy ; Bacteria ; Biological and medical sciences ; Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis ; Child ; Comorbidity ; Concise Clinical Review ; Disease Progression ; Female ; Hemoglobin ; Humans ; Hypertension, Pulmonary - diagnostic imaging ; Hypertension, Pulmonary - epidemiology ; Hypertension, Pulmonary - therapy ; Intensive care medicine ; Lipids ; Male ; Medical sciences ; Middle Aged ; Mortality ; Mutation ; Pathophysiology ; Patients ; Pediatrics ; Pneumonia ; Prognosis ; Pulmonary hypertension ; Radiography ; Risk Assessment ; Severity of Illness Index ; Sickle cell disease ; Staphylococcus infections ; Survival Analysis ; Transfusions. Complications. Transfusion reactions. 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The pulmonary complications of SCD are of particular importance, as acute chest syndrome and pulmonary hypertension have the highest associated mortality rates within this population. This article reviews the pathophysiology, diagnosis, and treatment of clinically significant pulmonary manifestations of SCD, including acute chest syndrome, asthma, and pulmonary hypertension in adult and pediatric patients. Clinicians should be vigilant in screening and treating such comorbidities to improve patient outcomes.</description><subject>Acute Chest Syndrome - diagnostic imaging</subject><subject>Acute Chest Syndrome - epidemiology</subject><subject>Acute Chest Syndrome - therapy</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Adults</subject><subject>Anemia</subject><subject>Anemia, Sickle Cell - diagnosis</subject><subject>Anemia, Sickle Cell - epidemiology</subject><subject>Anemia, Sickle Cell - therapy</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Asthma</subject><subject>Asthma - diagnostic imaging</subject><subject>Asthma - epidemiology</subject><subject>Asthma - therapy</subject><subject>Bacteria</subject><subject>Biological and medical sciences</subject><subject>Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis</subject><subject>Child</subject><subject>Comorbidity</subject><subject>Concise Clinical Review</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Hemoglobin</subject><subject>Humans</subject><subject>Hypertension, Pulmonary - diagnostic imaging</subject><subject>Hypertension, Pulmonary - epidemiology</subject><subject>Hypertension, Pulmonary - therapy</subject><subject>Intensive care medicine</subject><subject>Lipids</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Mutation</subject><subject>Pathophysiology</subject><subject>Patients</subject><subject>Pediatrics</subject><subject>Pneumonia</subject><subject>Prognosis</subject><subject>Pulmonary hypertension</subject><subject>Radiography</subject><subject>Risk Assessment</subject><subject>Severity of Illness Index</subject><subject>Sickle cell disease</subject><subject>Staphylococcus infections</subject><subject>Survival Analysis</subject><subject>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</subject><subject>Viral infections</subject><subject>Young Adult</subject><issn>1073-449X</issn><issn>1535-4970</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqNkUtLJDEURoM4-P4DLqRAhNlUm5tHJdkIUo4PEBR04S6k0imNVlXapEuYfz9pum1nXE02N5BzP-7NQegQ8ASgYqfR2n5CMORTEiyJ9RtoBzjlJVMCb-Y7FrRkTD1to92UXjEGIgFvoW1CGBOq4jtocj92fRhM_F3UoZ913pq5D0MqQls8ePvWuaJ2XVdc-ORMcvvoR2u65A5WdQ89Xv56rK_L27urm_r8trScq3kpTeUkx7ngRihqiABwlWENd4ZaTFrRTBWpGFFEMesUFeCEcS0wkLLhdA-dLWNnY9O7qXXDPJpOz6Lv86Q6GK__fRn8i34OH5pSQXElcsDPVUAM76NLc937ZPMiZnBhTBowlVwqQfh_oCArSgnQjB5_Q1_DGIf8EZkiIBRTCjJFlpSNIaXo2vXcgPVCnF6I00txeiGuvslNR39vvG75NJWBkxVgkjVdG81gffriuGJCqor-AeYfoBc</recordid><startdate>20120601</startdate><enddate>20120601</enddate><creator>MILLER, Andrew C</creator><creator>GLADWIN, Mark T</creator><general>American Thoracic Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>ASE</scope><scope>FPQ</scope><scope>K6X</scope><scope>5PM</scope></search><sort><creationdate>20120601</creationdate><title>Pulmonary Complications of Sickle Cell Disease</title><author>MILLER, Andrew C ; GLADWIN, Mark T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c559t-8a6e8508a60b793a2711e6a4b5ea3c02f7bd926429294ce9371e7aef14188b53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Acute Chest Syndrome - diagnostic imaging</topic><topic>Acute Chest Syndrome - epidemiology</topic><topic>Acute Chest Syndrome - therapy</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Adults</topic><topic>Anemia</topic><topic>Anemia, Sickle Cell - diagnosis</topic><topic>Anemia, Sickle Cell - epidemiology</topic><topic>Anemia, Sickle Cell - therapy</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Asthma</topic><topic>Asthma - diagnostic imaging</topic><topic>Asthma - epidemiology</topic><topic>Asthma - therapy</topic><topic>Bacteria</topic><topic>Biological and medical sciences</topic><topic>Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis</topic><topic>Child</topic><topic>Comorbidity</topic><topic>Concise Clinical Review</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Hemoglobin</topic><topic>Humans</topic><topic>Hypertension, Pulmonary - diagnostic imaging</topic><topic>Hypertension, Pulmonary - epidemiology</topic><topic>Hypertension, Pulmonary - therapy</topic><topic>Intensive care medicine</topic><topic>Lipids</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Mutation</topic><topic>Pathophysiology</topic><topic>Patients</topic><topic>Pediatrics</topic><topic>Pneumonia</topic><topic>Prognosis</topic><topic>Pulmonary hypertension</topic><topic>Radiography</topic><topic>Risk Assessment</topic><topic>Severity of Illness Index</topic><topic>Sickle cell disease</topic><topic>Staphylococcus infections</topic><topic>Survival Analysis</topic><topic>Transfusions. Complications. Transfusion reactions. 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The pulmonary complications of SCD are of particular importance, as acute chest syndrome and pulmonary hypertension have the highest associated mortality rates within this population. This article reviews the pathophysiology, diagnosis, and treatment of clinically significant pulmonary manifestations of SCD, including acute chest syndrome, asthma, and pulmonary hypertension in adult and pediatric patients. Clinicians should be vigilant in screening and treating such comorbidities to improve patient outcomes.</abstract><cop>New York, NY</cop><pub>American Thoracic Society</pub><pmid>22447965</pmid><doi>10.1164/rccm.201111-2082ci</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1073-449X |
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| issn | 1073-449X 1535-4970 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete; American Thoracic Society (ATS) Journals Online; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Acute Chest Syndrome - diagnostic imaging Acute Chest Syndrome - epidemiology Acute Chest Syndrome - therapy Adolescent Adult Adults Anemia Anemia, Sickle Cell - diagnosis Anemia, Sickle Cell - epidemiology Anemia, Sickle Cell - therapy Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Asthma Asthma - diagnostic imaging Asthma - epidemiology Asthma - therapy Bacteria Biological and medical sciences Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis Child Comorbidity Concise Clinical Review Disease Progression Female Hemoglobin Humans Hypertension, Pulmonary - diagnostic imaging Hypertension, Pulmonary - epidemiology Hypertension, Pulmonary - therapy Intensive care medicine Lipids Male Medical sciences Middle Aged Mortality Mutation Pathophysiology Patients Pediatrics Pneumonia Prognosis Pulmonary hypertension Radiography Risk Assessment Severity of Illness Index Sickle cell disease Staphylococcus infections Survival Analysis Transfusions. Complications. Transfusion reactions. Cell and gene therapy Viral infections Young Adult |
| title | Pulmonary Complications of Sickle Cell Disease |
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