Structure‐activity relationships of vanilloid receptor agonists for arteriolar TRPV1

BACKGROUND AND PURPOSE The transient receptor potential vanilloid 1 (TRPV1) plays a role in the activation of sensory neurons by various painful stimuli and is a therapeutic target. However, functional TRPV1 that affect microvascular diameter are also expressed in peripheral arteries and we attempte...

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Veröffentlicht in:	British journal of pharmacology 2012-03, Vol.165 (6), p.1801-1812
Hauptverfasser:	Czikora, Á, Lizanecz, E, Bakó, P, Rutkai, I, Ruzsnavszky, F, Magyar, J, Pórszász, R, Kark, T, Facskó, A, Papp, Z, Édes, I, Tóth, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylamides - pharmacology Animals Arterioles - drug effects Arterioles - physiology Biological and medical sciences Bridged Bicyclo Compounds, Heterocyclic - pharmacology Calcium - physiology Capsaicin - pharmacology CHO Cells Coronary Vessels - cytology Coronary Vessels - drug effects Coronary Vessels - physiology Cricetinae Cricetulus Dogs In Vitro Techniques Male Medical research Medical sciences Mice Mice, Inbred C57BL Mice, Knockout Muscle, Skeletal - blood supply Musculoskeletal system Myocytes, Smooth Muscle - drug effects Myocytes, Smooth Muscle - physiology Pharmacology. Drug treatments Rats Rats, Wistar Research Papers resistance artery Rodents Sensory Receptor Cells - physiology Smooth muscle Structure-Activity Relationship TRPV Cation Channels - agonists TRPV Cation Channels - antagonists & inhibitors TRPV Cation Channels - deficiency TRPV Cation Channels - physiology vanilloid receptor (TRPV1) vascular autoregulation Vasoconstriction - drug effects Vasoconstrictor Agents - chemistry Vasoconstrictor Agents - pharmacology
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