Lifting the lid on GPCRs: the role of extracellular loops

GPCRs exhibit a common architecture of seven transmembrane helices (TMs) linked by intracellular loops and extracellular loops (ECLs). Given their peripheral location to the site of G‐protein interaction, it might be assumed that ECL segments merely link the important TMs within the helical bundle o...

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Veröffentlicht in:	British journal of pharmacology 2012-03, Vol.165 (6), p.1688-1703
Hauptverfasser:	Wheatley, M, Wootten, D, Conner, MT, Simms, J, Kendrick, R, Logan, RT, Poyner, DR, Barwell, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Biological and medical sciences extracellular loop family A GPCR family B GPCR G‐protein coupled receptor Humans ligand binding Ligands Medical sciences Pharmacology. Drug treatments Protein Conformation receptor activation Receptors, G-Protein-Coupled - chemistry Receptors, G-Protein-Coupled - metabolism Reviews
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