MoRFpred, a computational tool for sequence-based prediction and characterization of short disorder-to-order transitioning binding regions in proteins

Molecular recognition features (MoRFs) are short binding regions located within longer intrinsically disordered regions that bind to protein partners via disorder-to-order transitions. MoRFs are implicated in important processes including signaling and regulation. However, only a limited number of e...

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Veröffentlicht in:	Bioinformatics (Oxford, England) England), 2012-06, Vol.28 (12), p.i75-i83
Hauptverfasser:	Disfani, Fatemeh Miri, Hsu, Wei-Lun, Mizianty, Marcin J, Oldfield, Christopher J, Xue, Bin, Dunker, A Keith, Uversky, Vladimir N, Kurgan, Lukasz
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids Binding Sites Computational Biology - methods Hydrophobic and Hydrophilic Interactions Molecular Sequence Annotation Original Papers Protein Structure, Secondary Proteins - analysis Sequence Alignment Support Vector Machine
Online-Zugang:	Volltext
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