Unstressing intemperate models: how cold stress undermines mouse modeling
Mus musculus enjoys pride of place at the center of contemporary biomedical research. Despite being the current model system of choice for in vivo mechanistic analysis, mice have clear limitations. The literature is littered with examples of therapeutic approaches that showed promise in mouse models...
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Veröffentlicht in: | The Journal of experimental medicine 2012-06, Vol.209 (6), p.1069-1074 |
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creator | Karp, Christopher L |
description | Mus musculus enjoys pride of place at the center of contemporary biomedical research. Despite being the current model system of choice for in vivo mechanistic analysis, mice have clear limitations. The literature is littered with examples of therapeutic approaches that showed promise in mouse models but failed in clinical trials. More generally, mice often provide poor mimics of the human diseases being modeled. Available data suggest that the cold stress to which laboratory mice are ubiquitously subjected profoundly affects mouse physiology in ways that impair the modeling of human homeostasis and disease. Experimental attention to this key, albeit largely ignored, environmental variable is likely to have a broad transformative effect on biomedical research. |
doi_str_mv | 10.1084/jem.20120988 |
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subjects | Animals Animals, Laboratory - physiology Cold-Shock Response - physiology Disease Models, Animal Humans Immune System - physiology Mice |
title | Unstressing intemperate models: how cold stress undermines mouse modeling |
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