Tackling Skeletal Muscle Cells Epigenome in the Next-Generation Sequencing Era

Recent advances in high-throughput technologies have transformed methodologies employed to study cell-specific epigenomes and the approaches to investigate complex cellular phenotypes. Application of next-generation sequencing technology in the skeletal muscle differentiation field is rapidly extend...

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Veröffentlicht in:Comparative and functional genomics 2012-01, Vol.2012 (2012), p.1-8
Hauptverfasser: Fittipaldi, Raffaella, Caretti, Giuseppina
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container_title Comparative and functional genomics
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creator Fittipaldi, Raffaella
Caretti, Giuseppina
description Recent advances in high-throughput technologies have transformed methodologies employed to study cell-specific epigenomes and the approaches to investigate complex cellular phenotypes. Application of next-generation sequencing technology in the skeletal muscle differentiation field is rapidly extending our knowledge on how chromatin modifications, transcription factors and chromatin regulators orchestrate gene expression pathways guiding myogenesis. Here, we review recent biological insights gained by the application of next-generation sequencing techniques to decode the epigenetic profile and gene regulatory networks underlying skeletal muscle differentiation.
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subjects Chromatin
Differentiation
epigenetics
Gene expression
myogenesis
Review
Reviews
Skeletal muscle
Transcription factors
title Tackling Skeletal Muscle Cells Epigenome in the Next-Generation Sequencing Era
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