Evaluation of anti-ulcer effect of amlodipine in gastric ulcer models in rats
To study anti-ulcer effect of Amlodipine and compared it with ranitidine in indomethacin, alcohol and pyloric ligation-induced gastric ulcers in wistar rats. Gastric ulcers were induced in Wistar albino rats by oral administration of indomethacin (200 mg/kg), alcohol (80%, 1 ml/100 gm) and by pylori...
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| Veröffentlicht in: | Indian journal of pharmacology 2012-05, Vol.44 (3), p.387-389 |
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| container_title | Indian journal of pharmacology |
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| creator | Patil, Amol N Advani, Manjari G Mali, S N Pawar, Sudhir Raut, Sanket B |
| description | To study anti-ulcer effect of Amlodipine and compared it with ranitidine in indomethacin, alcohol and pyloric ligation-induced gastric ulcers in wistar rats.
Gastric ulcers were induced in Wistar albino rats by oral administration of indomethacin (200 mg/kg), alcohol (80%, 1 ml/100 gm) and by pyloric ligation. Antiulcer activity of amlodipine (0.5 mg/kg, i.p.) was observed either alone or in combination with ranitidine (15 mg/kg, i.p.), on ulcer index, gastric pH and gastric volume. Statistical analysis was done by ANOVA and unpaired one tailed 't' test. P |
| doi_str_mv | 10.4103/0253-7613.96344 |
| format | Article |
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Gastric ulcers were induced in Wistar albino rats by oral administration of indomethacin (200 mg/kg), alcohol (80%, 1 ml/100 gm) and by pyloric ligation. Antiulcer activity of amlodipine (0.5 mg/kg, i.p.) was observed either alone or in combination with ranitidine (15 mg/kg, i.p.), on ulcer index, gastric pH and gastric volume. Statistical analysis was done by ANOVA and unpaired one tailed 't' test. P<0.05 was considered statistically significant.
Amlodipine produced significant (P<0.05) decrease in ulcer index and gastric pH as compared to control. It also produced significant (P<0.05) increase in gastric volume as compared to ranitidine. The anti-ulcer effects of ranitidine were significantly higher than that of amlodipine. Combination of amlodipine and ranitidine did not show significant increase in anti-ulcer activity as compared with ranitidine alone.
Amlodipine produced significant anti-ulcer effects in all 3 experimental models. Amlodipine increased the volume of gastric secretions as compared to ranitidine.</description><identifier>ISSN: 0253-7613</identifier><identifier>EISSN: 1998-3751</identifier><identifier>DOI: 10.4103/0253-7613.96344</identifier><identifier>PMID: 22701252</identifier><language>eng</language><publisher>India: Medknow Publications and Media Pvt. Ltd</publisher><subject>Amlodipine ; Drug therapy ; Drugs ; Gastrointestinal diseases ; Health aspects ; Pharmacology ; Rodents ; Short Communication ; Stomach ulcer ; Ulcers</subject><ispartof>Indian journal of pharmacology, 2012-05, Vol.44 (3), p.387-389</ispartof><rights>COPYRIGHT 2012 Medknow Publications and Media Pvt. Ltd.</rights><rights>Copyright Medknow Publications & Media Pvt Ltd May/Jun 2012</rights><rights>Copyright: © Indian Journal of Pharmacology 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c526t-ddb197c5eda0c57b6be4d86e6f94e32915702e017c3b3b87a95ef0badcc851003</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371465/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371465/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27922,27923,53789,53791</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22701252$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Patil, Amol N</creatorcontrib><creatorcontrib>Advani, Manjari G</creatorcontrib><creatorcontrib>Mali, S N</creatorcontrib><creatorcontrib>Pawar, Sudhir</creatorcontrib><creatorcontrib>Raut, Sanket B</creatorcontrib><title>Evaluation of anti-ulcer effect of amlodipine in gastric ulcer models in rats</title><title>Indian journal of pharmacology</title><addtitle>Indian J Pharmacol</addtitle><description>To study anti-ulcer effect of Amlodipine and compared it with ranitidine in indomethacin, alcohol and pyloric ligation-induced gastric ulcers in wistar rats.
Gastric ulcers were induced in Wistar albino rats by oral administration of indomethacin (200 mg/kg), alcohol (80%, 1 ml/100 gm) and by pyloric ligation. Antiulcer activity of amlodipine (0.5 mg/kg, i.p.) was observed either alone or in combination with ranitidine (15 mg/kg, i.p.), on ulcer index, gastric pH and gastric volume. Statistical analysis was done by ANOVA and unpaired one tailed 't' test. P<0.05 was considered statistically significant.
Amlodipine produced significant (P<0.05) decrease in ulcer index and gastric pH as compared to control. It also produced significant (P<0.05) increase in gastric volume as compared to ranitidine. The anti-ulcer effects of ranitidine were significantly higher than that of amlodipine. Combination of amlodipine and ranitidine did not show significant increase in anti-ulcer activity as compared with ranitidine alone.
Amlodipine produced significant anti-ulcer effects in all 3 experimental models. Amlodipine increased the volume of gastric secretions as compared to ranitidine.</description><subject>Amlodipine</subject><subject>Drug therapy</subject><subject>Drugs</subject><subject>Gastrointestinal diseases</subject><subject>Health aspects</subject><subject>Pharmacology</subject><subject>Rodents</subject><subject>Short Communication</subject><subject>Stomach ulcer</subject><subject>Ulcers</subject><issn>0253-7613</issn><issn>1998-3751</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptkk1v1DAQhi0EokvhzA1F4sIlW3_EdnxBqqryIRVxgbPlOOPFlWMvdlKJf4_TLQtFKx8szzzzemb0IvSa4G1HMLvAlLNWCsK2SrCue4I2RKm-ZZKTp2hzzJ6hF6Xc4vrulHiOziiVmFBON-jL9Z0Ji5l9ik1yjYmzb5dgITfgHNj5PjiFNPq9j9D42OxMmbO3zYGa0gihrPFs5vISPXMmFHj1cJ-j7x-uv119am--fvx8dXnTWk7F3I7jQJS0HEaDLZeDGKAbewHCqQ4YVYRLTAETadnAhl4axcHhwYzW9pxgzM7R-4PufhkmGC3EOZug99lPJv_SyXj9OBP9D71Ld5oxSTrBq8C7B4Gcfi5QZj35YiEEEyEtRRNMcU-lwqyib_9Db9OSYx1vpQjhihH1l9qZANpHl-q_dhXVl3Ug2gsu1r7bE9QOItQmUwTna_gRvz3B1zPC5O3JgotDgc2plAzuuBOC9eoYvXpCr57Q946pFW_-XeWR_2MR9htt8LmW</recordid><startdate>20120501</startdate><enddate>20120501</enddate><creator>Patil, Amol N</creator><creator>Advani, Manjari G</creator><creator>Mali, S N</creator><creator>Pawar, Sudhir</creator><creator>Raut, Sanket B</creator><general>Medknow Publications and Media Pvt. 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Gastric ulcers were induced in Wistar albino rats by oral administration of indomethacin (200 mg/kg), alcohol (80%, 1 ml/100 gm) and by pyloric ligation. Antiulcer activity of amlodipine (0.5 mg/kg, i.p.) was observed either alone or in combination with ranitidine (15 mg/kg, i.p.), on ulcer index, gastric pH and gastric volume. Statistical analysis was done by ANOVA and unpaired one tailed 't' test. P<0.05 was considered statistically significant.
Amlodipine produced significant (P<0.05) decrease in ulcer index and gastric pH as compared to control. It also produced significant (P<0.05) increase in gastric volume as compared to ranitidine. The anti-ulcer effects of ranitidine were significantly higher than that of amlodipine. Combination of amlodipine and ranitidine did not show significant increase in anti-ulcer activity as compared with ranitidine alone.
Amlodipine produced significant anti-ulcer effects in all 3 experimental models. Amlodipine increased the volume of gastric secretions as compared to ranitidine.</abstract><cop>India</cop><pub>Medknow Publications and Media Pvt. Ltd</pub><pmid>22701252</pmid><doi>10.4103/0253-7613.96344</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Indian journal of pharmacology, 2012-05, Vol.44 (3), p.387-389 |
| issn | 0253-7613 1998-3751 |
| language | eng |
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| source | PubMed Central Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Amlodipine Drug therapy Drugs Gastrointestinal diseases Health aspects Pharmacology Rodents Short Communication Stomach ulcer Ulcers |
| title | Evaluation of anti-ulcer effect of amlodipine in gastric ulcer models in rats |
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