Intravaginal ring delivery of tenofovir disoproxil fumarate for prevention of HIV and herpes simplex virus infection

A safe and effective topical prevention strategy will likely require sustained delivery of potent antiviral drugs and a delivery system that simultaneously maximizes drug distribution and overcomes the behavioural challenges related to adherence. Activity against HIV and herpes simplex virus (HSV) w...

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Veröffentlicht in:	Journal of antimicrobial chemotherapy 2012-07, Vol.67 (7), p.1730-1738
Hauptverfasser:	MESQUITA, Pedro M. M, RASTOGI, Rachna, SEGARRA, Theodore J, TELLER, Ryan S, TORRES, N. Merna, HUBER, Ashley M, KISER, Patrick F, HEROLD, Betsy C
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetic acid Adenine - analogs & derivatives Adenine - pharmacology Antibiotics. Antiinfectious agents. Antiparasitic agents Antiretroviral drugs Antiviral agents Antiviral Agents - pharmacology Biological and medical sciences Cell culture Cell Culture Techniques Chemoprevention - methods Contraceptive Devices, Female Drug delivery Drug development Epidemiology Explants Female Herpes Genitalis - prevention & control Herpes simplex virus 2 Herpes viruses HIV HIV - drug effects HIV Infections - prevention & control Human immunodeficiency virus Human viral diseases Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Infection Infectious diseases Medical sciences Organ Culture Techniques Organophosphonates - pharmacology Original Research Pathogens Pharmacology Pharmacology. Drug treatments Polarization polyethers prodrugs Semen Silicones Simplexvirus - drug effects Tenofovir urethane Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye
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