Ovarian tissue cryopreservation for fertility preservation in cancer patients: Successful establishment and feasibility of a multidisciplinary collaboration
Background As advancements in cancer therapies have led to dramatic improvements in long term survival, there has been increasing interest in methods to expand fertility preservation options for cancer patients. Methods An experimental protocol for ovarian tissue cryopreservation was developed at th...
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| Veröffentlicht in: | Journal of assisted reproduction and genetics 2012-06, Vol.29 (6), p.495-502 |
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| container_title | Journal of assisted reproduction and genetics |
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| creator | Gracia, Clarisa R. Chang, Jeff Kondapalli, Laxmi Prewitt, Maureen Carlson, Claire A. Mattei, Peter Jeffers, Shanaye Ginsberg, Jill P. |
| description | Background
As advancements in cancer therapies have led to dramatic improvements in long term survival, there has been increasing interest in methods to expand fertility preservation options for cancer patients.
Methods
An experimental protocol for ovarian tissue cryopreservation was developed at the University of Pennsylvania for patients requiring gonadotoxic therapies. The protocol for adults was implemented at the Hospital of the University of Pennsylvania and for children at the Children’s Hospital of Philadelphia in collaboration with the Oncofertility Consortium and the National Physicians Cooperative (NPC).
Results
A total of twenty-one patients (age range: 8–36 years) have cryopreserved ovarian tissue as part of this study. While patients had a variety of diagnoses and treatment exposures, 10/21 (48 %) patients suffered from hematologic disorders and 43 % were anticipating stem cell transplantation. No patients have requested that the tissue be used for clinical purposes.
Conclusions
Ovarian tissue cryopreservation protocols can be implemented at pediatric and adult institutions through multi-disciplinary collaboration. While more research is needed to determine the safety and efficacy of ovarian tissue cryopreservation, this procedure provides hope for preserving the ability to have biological offspring to patients facing gonadotoxic therapies for a variety of medical conditions. |
| doi_str_mv | 10.1007/s10815-012-9753-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3370042</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1019615885</sourcerecordid><originalsourceid>FETCH-LOGICAL-c503t-eacfb2456e5da3782bfda486904ef2166214993454494de99edb7f8d58631da03</originalsourceid><addsrcrecordid>eNqNks1qFjEUhgdRbK1egBsJuHEzevI7iQuhFP-g0IW6DplM0qbMJGMy88F3L16s-Tq1tILgKoecJ-85b3ib5iWGtxige1cwSMxbwKRVHadt96g5xryrBaXwuNbAZQtMyKPmWSnXAKAkoU-bI0KYEB3jx82vi53JwUS0hFJWh2zepzm74vLOLCFF5FNG3uUljGHZowetEJE10bqM5nrh4lLeo2-rta4Uv47IlcX0YyhXU20hE4eqY0roN6XkkUHTOi5hCMWGeQzR5D2yaRxNn_LNhOfNE2_G4l7cnifNj08fv599ac8vPn89Oz1vLQe6tM5Y3xPGheODoZ0kvR8Mk0IBc55gIQhmSlHGGVNscEq5oe-8HLgUFA8G6EnzYdOd135yg637ZjPqOYep7qSTCfphJ4YrfZl2mtIOgJEq8OZWIKefazWup2rKVSvRpbVoDIfxFNT_oFgJzKXkFX39F3qd1hzrT9xQIAWmuFJ4o2xOpWTn7_bGoA8x0VtMdI2JPsREd_XNq_uG7178yUUFyAaU2oqXLt8f_S_V37EWzXY</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1019086131</pqid></control><display><type>article</type><title>Ovarian tissue cryopreservation for fertility preservation in cancer patients: Successful establishment and feasibility of a multidisciplinary collaboration</title><source>MEDLINE</source><source>SpringerLink Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Gracia, Clarisa R. ; Chang, Jeff ; Kondapalli, Laxmi ; Prewitt, Maureen ; Carlson, Claire A. ; Mattei, Peter ; Jeffers, Shanaye ; Ginsberg, Jill P.</creator><creatorcontrib>Gracia, Clarisa R. ; Chang, Jeff ; Kondapalli, Laxmi ; Prewitt, Maureen ; Carlson, Claire A. ; Mattei, Peter ; Jeffers, Shanaye ; Ginsberg, Jill P.</creatorcontrib><description>Background
As advancements in cancer therapies have led to dramatic improvements in long term survival, there has been increasing interest in methods to expand fertility preservation options for cancer patients.
Methods
An experimental protocol for ovarian tissue cryopreservation was developed at the University of Pennsylvania for patients requiring gonadotoxic therapies. The protocol for adults was implemented at the Hospital of the University of Pennsylvania and for children at the Children’s Hospital of Philadelphia in collaboration with the Oncofertility Consortium and the National Physicians Cooperative (NPC).
Results
A total of twenty-one patients (age range: 8–36 years) have cryopreserved ovarian tissue as part of this study. While patients had a variety of diagnoses and treatment exposures, 10/21 (48 %) patients suffered from hematologic disorders and 43 % were anticipating stem cell transplantation. No patients have requested that the tissue be used for clinical purposes.
Conclusions
Ovarian tissue cryopreservation protocols can be implemented at pediatric and adult institutions through multi-disciplinary collaboration. While more research is needed to determine the safety and efficacy of ovarian tissue cryopreservation, this procedure provides hope for preserving the ability to have biological offspring to patients facing gonadotoxic therapies for a variety of medical conditions.</description><identifier>ISSN: 1058-0468</identifier><identifier>EISSN: 1573-7330</identifier><identifier>DOI: 10.1007/s10815-012-9753-7</identifier><identifier>PMID: 22466745</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Adolescent ; Adult ; Age ; Biopsy ; Cancer therapies ; Child ; Collaboration ; Consortia ; Cryopreservation ; Cryopreservation - methods ; Endocrinology ; Female ; Fertility ; Fertility Preservation ; Fertility Preservation - methods ; Gynecology ; Hematologic Neoplasms - therapy ; Hospitals ; Human Genetics ; Humans ; Infertility ; Medicine ; Medicine & Public Health ; Neoplasms - therapy ; Ovaries ; Ovary - physiology ; Ovary - surgery ; Pediatrics ; Quality of life ; Reproductive Medicine ; Stem cells ; Surgeons ; Surgical outcomes ; Transplants & implants ; Young Adult</subject><ispartof>Journal of assisted reproduction and genetics, 2012-06, Vol.29 (6), p.495-502</ispartof><rights>Springer Science+Business Media, LLC 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c503t-eacfb2456e5da3782bfda486904ef2166214993454494de99edb7f8d58631da03</citedby><cites>FETCH-LOGICAL-c503t-eacfb2456e5da3782bfda486904ef2166214993454494de99edb7f8d58631da03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3370042/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3370042/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,41464,42533,51294,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22466745$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gracia, Clarisa R.</creatorcontrib><creatorcontrib>Chang, Jeff</creatorcontrib><creatorcontrib>Kondapalli, Laxmi</creatorcontrib><creatorcontrib>Prewitt, Maureen</creatorcontrib><creatorcontrib>Carlson, Claire A.</creatorcontrib><creatorcontrib>Mattei, Peter</creatorcontrib><creatorcontrib>Jeffers, Shanaye</creatorcontrib><creatorcontrib>Ginsberg, Jill P.</creatorcontrib><title>Ovarian tissue cryopreservation for fertility preservation in cancer patients: Successful establishment and feasibility of a multidisciplinary collaboration</title><title>Journal of assisted reproduction and genetics</title><addtitle>J Assist Reprod Genet</addtitle><addtitle>J Assist Reprod Genet</addtitle><description>Background
As advancements in cancer therapies have led to dramatic improvements in long term survival, there has been increasing interest in methods to expand fertility preservation options for cancer patients.
Methods
An experimental protocol for ovarian tissue cryopreservation was developed at the University of Pennsylvania for patients requiring gonadotoxic therapies. The protocol for adults was implemented at the Hospital of the University of Pennsylvania and for children at the Children’s Hospital of Philadelphia in collaboration with the Oncofertility Consortium and the National Physicians Cooperative (NPC).
Results
A total of twenty-one patients (age range: 8–36 years) have cryopreserved ovarian tissue as part of this study. While patients had a variety of diagnoses and treatment exposures, 10/21 (48 %) patients suffered from hematologic disorders and 43 % were anticipating stem cell transplantation. No patients have requested that the tissue be used for clinical purposes.
Conclusions
Ovarian tissue cryopreservation protocols can be implemented at pediatric and adult institutions through multi-disciplinary collaboration. While more research is needed to determine the safety and efficacy of ovarian tissue cryopreservation, this procedure provides hope for preserving the ability to have biological offspring to patients facing gonadotoxic therapies for a variety of medical conditions.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age</subject><subject>Biopsy</subject><subject>Cancer therapies</subject><subject>Child</subject><subject>Collaboration</subject><subject>Consortia</subject><subject>Cryopreservation</subject><subject>Cryopreservation - methods</subject><subject>Endocrinology</subject><subject>Female</subject><subject>Fertility</subject><subject>Fertility Preservation</subject><subject>Fertility Preservation - methods</subject><subject>Gynecology</subject><subject>Hematologic Neoplasms - therapy</subject><subject>Hospitals</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Infertility</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neoplasms - therapy</subject><subject>Ovaries</subject><subject>Ovary - physiology</subject><subject>Ovary - surgery</subject><subject>Pediatrics</subject><subject>Quality of life</subject><subject>Reproductive Medicine</subject><subject>Stem cells</subject><subject>Surgeons</subject><subject>Surgical outcomes</subject><subject>Transplants & implants</subject><subject>Young Adult</subject><issn>1058-0468</issn><issn>1573-7330</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNks1qFjEUhgdRbK1egBsJuHEzevI7iQuhFP-g0IW6DplM0qbMJGMy88F3L16s-Tq1tILgKoecJ-85b3ib5iWGtxige1cwSMxbwKRVHadt96g5xryrBaXwuNbAZQtMyKPmWSnXAKAkoU-bI0KYEB3jx82vi53JwUS0hFJWh2zepzm74vLOLCFF5FNG3uUljGHZowetEJE10bqM5nrh4lLeo2-rta4Uv47IlcX0YyhXU20hE4eqY0roN6XkkUHTOi5hCMWGeQzR5D2yaRxNn_LNhOfNE2_G4l7cnifNj08fv599ac8vPn89Oz1vLQe6tM5Y3xPGheODoZ0kvR8Mk0IBc55gIQhmSlHGGVNscEq5oe-8HLgUFA8G6EnzYdOd135yg637ZjPqOYep7qSTCfphJ4YrfZl2mtIOgJEq8OZWIKefazWup2rKVSvRpbVoDIfxFNT_oFgJzKXkFX39F3qd1hzrT9xQIAWmuFJ4o2xOpWTn7_bGoA8x0VtMdI2JPsREd_XNq_uG7178yUUFyAaU2oqXLt8f_S_V37EWzXY</recordid><startdate>20120601</startdate><enddate>20120601</enddate><creator>Gracia, Clarisa R.</creator><creator>Chang, Jeff</creator><creator>Kondapalli, Laxmi</creator><creator>Prewitt, Maureen</creator><creator>Carlson, Claire A.</creator><creator>Mattei, Peter</creator><creator>Jeffers, Shanaye</creator><creator>Ginsberg, Jill P.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope><scope>7QO</scope><scope>5PM</scope></search><sort><creationdate>20120601</creationdate><title>Ovarian tissue cryopreservation for fertility preservation in cancer patients: Successful establishment and feasibility of a multidisciplinary collaboration</title><author>Gracia, Clarisa R. ; Chang, Jeff ; Kondapalli, Laxmi ; Prewitt, Maureen ; Carlson, Claire A. ; Mattei, Peter ; Jeffers, Shanaye ; Ginsberg, Jill P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c503t-eacfb2456e5da3782bfda486904ef2166214993454494de99edb7f8d58631da03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age</topic><topic>Biopsy</topic><topic>Cancer therapies</topic><topic>Child</topic><topic>Collaboration</topic><topic>Consortia</topic><topic>Cryopreservation</topic><topic>Cryopreservation - methods</topic><topic>Endocrinology</topic><topic>Female</topic><topic>Fertility</topic><topic>Fertility Preservation</topic><topic>Fertility Preservation - methods</topic><topic>Gynecology</topic><topic>Hematologic Neoplasms - therapy</topic><topic>Hospitals</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>Infertility</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neoplasms - therapy</topic><topic>Ovaries</topic><topic>Ovary - physiology</topic><topic>Ovary - surgery</topic><topic>Pediatrics</topic><topic>Quality of life</topic><topic>Reproductive Medicine</topic><topic>Stem cells</topic><topic>Surgeons</topic><topic>Surgical outcomes</topic><topic>Transplants & implants</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gracia, Clarisa R.</creatorcontrib><creatorcontrib>Chang, Jeff</creatorcontrib><creatorcontrib>Kondapalli, Laxmi</creatorcontrib><creatorcontrib>Prewitt, Maureen</creatorcontrib><creatorcontrib>Carlson, Claire A.</creatorcontrib><creatorcontrib>Mattei, Peter</creatorcontrib><creatorcontrib>Jeffers, Shanaye</creatorcontrib><creatorcontrib>Ginsberg, Jill P.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of assisted reproduction and genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gracia, Clarisa R.</au><au>Chang, Jeff</au><au>Kondapalli, Laxmi</au><au>Prewitt, Maureen</au><au>Carlson, Claire A.</au><au>Mattei, Peter</au><au>Jeffers, Shanaye</au><au>Ginsberg, Jill P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ovarian tissue cryopreservation for fertility preservation in cancer patients: Successful establishment and feasibility of a multidisciplinary collaboration</atitle><jtitle>Journal of assisted reproduction and genetics</jtitle><stitle>J Assist Reprod Genet</stitle><addtitle>J Assist Reprod Genet</addtitle><date>2012-06-01</date><risdate>2012</risdate><volume>29</volume><issue>6</issue><spage>495</spage><epage>502</epage><pages>495-502</pages><issn>1058-0468</issn><eissn>1573-7330</eissn><abstract>Background
As advancements in cancer therapies have led to dramatic improvements in long term survival, there has been increasing interest in methods to expand fertility preservation options for cancer patients.
Methods
An experimental protocol for ovarian tissue cryopreservation was developed at the University of Pennsylvania for patients requiring gonadotoxic therapies. The protocol for adults was implemented at the Hospital of the University of Pennsylvania and for children at the Children’s Hospital of Philadelphia in collaboration with the Oncofertility Consortium and the National Physicians Cooperative (NPC).
Results
A total of twenty-one patients (age range: 8–36 years) have cryopreserved ovarian tissue as part of this study. While patients had a variety of diagnoses and treatment exposures, 10/21 (48 %) patients suffered from hematologic disorders and 43 % were anticipating stem cell transplantation. No patients have requested that the tissue be used for clinical purposes.
Conclusions
Ovarian tissue cryopreservation protocols can be implemented at pediatric and adult institutions through multi-disciplinary collaboration. While more research is needed to determine the safety and efficacy of ovarian tissue cryopreservation, this procedure provides hope for preserving the ability to have biological offspring to patients facing gonadotoxic therapies for a variety of medical conditions.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>22466745</pmid><doi>10.1007/s10815-012-9753-7</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; SpringerLink Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Adolescent Adult Age Biopsy Cancer therapies Child Collaboration Consortia Cryopreservation Cryopreservation - methods Endocrinology Female Fertility Fertility Preservation Fertility Preservation - methods Gynecology Hematologic Neoplasms - therapy Hospitals Human Genetics Humans Infertility Medicine Medicine & Public Health Neoplasms - therapy Ovaries Ovary - physiology Ovary - surgery Pediatrics Quality of life Reproductive Medicine Stem cells Surgeons Surgical outcomes Transplants & implants Young Adult |
| title | Ovarian tissue cryopreservation for fertility preservation in cancer patients: Successful establishment and feasibility of a multidisciplinary collaboration |
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