Family history influences the early onset of hepatocellular carcinoma
AIM： To evaluate the relationship between a positive family history of primary liver cancer and hepatocellular carcinoma （HCC） development in Korean HCC patients. METHODS： We studied a total of 2242 patients diagnosed with HCC between January 1990 and July 2008, whose family history of primary liver...
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| Veröffentlicht in: | World journal of gastroenterology : WJG 2012-06, Vol.18 (21), p.2661-2667 |
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| container_title | World journal of gastroenterology : WJG |
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| creator | Park, Chung-Hwa Jeong, Seung-Hee Yim, Hyeon-Woo Kim, Jin Dong Bae, Si Hyun Choi, Jong Young Yoon, Seung Kew |
| description | AIM： To evaluate the relationship between a positive family history of primary liver cancer and hepatocellular carcinoma （HCC） development in Korean HCC patients. METHODS： We studied a total of 2242 patients diagnosed with HCC between January 1990 and July 2008, whose family history of primary liver cancer was clearly described in the medical records.positive family history of HCC and 2077 （92.6%） did not. The male to female ratio was 3.6：1, and the major causes of HCC were chronic hepatitis B virus （HBV） infection in 75.1%, chronic hepatitis C virus infection in 13.2% and alcohol in 3.1%. The median ages at diag- nosis in the positiveand negative-history groups were 52 years （range： 29-79 years） and 57 years （range： 18-89 years）, respectively （P 〈 0.0001）. Furthermore, among 1713 HCC patients with HBV infection, the number of patients under 45 years of age out of 136 patients with positive family history was 26 （19.1%）, whereas those out of 1577 patients with negative family history was 197 （12.5%）, suggesting that a positive family history may be associated with earlier development of HCC in the Korean population （P = 0.0028）. CONCLUSION： More intensive surveillance maybe recommended to those with a positive family history of HCC for earlier diagnosis and proper management especially when HBV infection is present. |
| doi_str_mv | 10.3748/wjg.v18.i21.2661 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3370003</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><cqvip_id>42326942</cqvip_id><sourcerecordid>22690075</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4031-f5bbb6dc8a6d20507340da72fa27890c58834fe905258ad21ca04381a3af37393</originalsourceid><addsrcrecordid>eNpVkM9LwzAYhoMobk7vnqT-Aa1fkv5IL4KMTYWBFz2Hr2naZrTNTLvJ_nszpkMv-Q7v-z6Bh5BbChHPYvHwta6jHRWRYTRiaUrPyJQxmodMxHBOphQgC3POsgm5GoY1AOM8YZdkwlia-yyZksUSO9Pug8YMo3X7wPRVu9W90kMwNjrQ6Hxo-0GPga2CRm9wtEq37bZFFyh0yvS2w2tyUWE76JufOyMfy8X7_CVcvT2_zp9WoYqB07BKiqJISyUwLRkkkPEYSsxYhSwTOahECB5XOoeEJQJLRhVCzAVFjhXPeM5n5PHI3WyLTpdK96PDVm6c6dDtpUUj_ye9aWRtd5LzDAC4B8ARoJwdBqer05aCPCiVXqn0SqVXKg9K_eTu75-nwa9DX7j_YTa2rz9NX586MeO-5d9voEOABQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Family history influences the early onset of hepatocellular carcinoma</title><source>MEDLINE</source><source>Baishideng "World Journal of" online journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Park, Chung-Hwa ; Jeong, Seung-Hee ; Yim, Hyeon-Woo ; Kim, Jin Dong ; Bae, Si Hyun ; Choi, Jong Young ; Yoon, Seung Kew</creator><creatorcontrib>Park, Chung-Hwa ; Jeong, Seung-Hee ; Yim, Hyeon-Woo ; Kim, Jin Dong ; Bae, Si Hyun ; Choi, Jong Young ; Yoon, Seung Kew</creatorcontrib><description>AIM： To evaluate the relationship between a positive family history of primary liver cancer and hepatocellular carcinoma （HCC） development in Korean HCC patients. METHODS： We studied a total of 2242 patients diagnosed with HCC between January 1990 and July 2008, whose family history of primary liver cancer was clearly described in the medical records.positive family history of HCC and 2077 （92.6%） did not. The male to female ratio was 3.6：1, and the major causes of HCC were chronic hepatitis B virus （HBV） infection in 75.1%, chronic hepatitis C virus infection in 13.2% and alcohol in 3.1%. The median ages at diag- nosis in the positiveand negative-history groups were 52 years （range： 29-79 years） and 57 years （range： 18-89 years）, respectively （P 〈 0.0001）. Furthermore, among 1713 HCC patients with HBV infection, the number of patients under 45 years of age out of 136 patients with positive family history was 26 （19.1%）, whereas those out of 1577 patients with negative family history was 197 （12.5%）, suggesting that a positive family history may be associated with earlier development of HCC in the Korean population （P = 0.0028）. CONCLUSION： More intensive surveillance maybe recommended to those with a positive family history of HCC for earlier diagnosis and proper management especially when HBV infection is present.</description><identifier>ISSN: 1007-9327</identifier><identifier>EISSN: 2219-2840</identifier><identifier>DOI: 10.3748/wjg.v18.i21.2661</identifier><identifier>PMID: 22690075</identifier><language>eng</language><publisher>United States: Baishideng Publishing Group Co., Limited</publisher><subject>Adolescent ; Adult ; Age of Onset ; Aged ; Aged, 80 and over ; Alcoholism - complications ; Brief ; Carcinoma, Hepatocellular - diagnosis ; Carcinoma, Hepatocellular - ethnology ; Carcinoma, Hepatocellular - genetics ; Family Health ; Female ; Genetic Predisposition to Disease ; Hepatitis B, Chronic - complications ; Hepatitis C, Chronic - complications ; Humans ; Korea ; Liver Neoplasms - diagnosis ; Liver Neoplasms - ethnology ; Liver Neoplasms - genetics ; Male ; Middle Aged ; Retrospective Studies ; Risk Factors ; 丙型肝炎 ; 乙型肝炎病毒 ; 原发性肝癌 ; 发病 ; 家族史 ; 早期诊断 ; 病毒感染 ; 肝细胞癌</subject><ispartof>World journal of gastroenterology : WJG, 2012-06, Vol.18 (21), p.2661-2667</ispartof><rights>2012 Baishideng Publishing Group Co., Limited. All rights reserved. 2012</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4031-f5bbb6dc8a6d20507340da72fa27890c58834fe905258ad21ca04381a3af37393</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/84123X/84123X.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3370003/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3370003/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,724,777,781,882,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22690075$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Park, Chung-Hwa</creatorcontrib><creatorcontrib>Jeong, Seung-Hee</creatorcontrib><creatorcontrib>Yim, Hyeon-Woo</creatorcontrib><creatorcontrib>Kim, Jin Dong</creatorcontrib><creatorcontrib>Bae, Si Hyun</creatorcontrib><creatorcontrib>Choi, Jong Young</creatorcontrib><creatorcontrib>Yoon, Seung Kew</creatorcontrib><title>Family history influences the early onset of hepatocellular carcinoma</title><title>World journal of gastroenterology : WJG</title><addtitle>World Journal of Gastroenterology</addtitle><description>AIM： To evaluate the relationship between a positive family history of primary liver cancer and hepatocellular carcinoma （HCC） development in Korean HCC patients. METHODS： We studied a total of 2242 patients diagnosed with HCC between January 1990 and July 2008, whose family history of primary liver cancer was clearly described in the medical records.positive family history of HCC and 2077 （92.6%） did not. The male to female ratio was 3.6：1, and the major causes of HCC were chronic hepatitis B virus （HBV） infection in 75.1%, chronic hepatitis C virus infection in 13.2% and alcohol in 3.1%. The median ages at diag- nosis in the positiveand negative-history groups were 52 years （range： 29-79 years） and 57 years （range： 18-89 years）, respectively （P 〈 0.0001）. Furthermore, among 1713 HCC patients with HBV infection, the number of patients under 45 years of age out of 136 patients with positive family history was 26 （19.1%）, whereas those out of 1577 patients with negative family history was 197 （12.5%）, suggesting that a positive family history may be associated with earlier development of HCC in the Korean population （P = 0.0028）. CONCLUSION： More intensive surveillance maybe recommended to those with a positive family history of HCC for earlier diagnosis and proper management especially when HBV infection is present.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age of Onset</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alcoholism - complications</subject><subject>Brief</subject><subject>Carcinoma, Hepatocellular - diagnosis</subject><subject>Carcinoma, Hepatocellular - ethnology</subject><subject>Carcinoma, Hepatocellular - genetics</subject><subject>Family Health</subject><subject>Female</subject><subject>Genetic Predisposition to Disease</subject><subject>Hepatitis B, Chronic - complications</subject><subject>Hepatitis C, Chronic - complications</subject><subject>Humans</subject><subject>Korea</subject><subject>Liver Neoplasms - diagnosis</subject><subject>Liver Neoplasms - ethnology</subject><subject>Liver Neoplasms - genetics</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>丙型肝炎</subject><subject>乙型肝炎病毒</subject><subject>原发性肝癌</subject><subject>发病</subject><subject>家族史</subject><subject>早期诊断</subject><subject>病毒感染</subject><subject>肝细胞癌</subject><issn>1007-9327</issn><issn>2219-2840</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkM9LwzAYhoMobk7vnqT-Aa1fkv5IL4KMTYWBFz2Hr2naZrTNTLvJ_nszpkMv-Q7v-z6Bh5BbChHPYvHwta6jHRWRYTRiaUrPyJQxmodMxHBOphQgC3POsgm5GoY1AOM8YZdkwlia-yyZksUSO9Pug8YMo3X7wPRVu9W90kMwNjrQ6Hxo-0GPga2CRm9wtEq37bZFFyh0yvS2w2tyUWE76JufOyMfy8X7_CVcvT2_zp9WoYqB07BKiqJISyUwLRkkkPEYSsxYhSwTOahECB5XOoeEJQJLRhVCzAVFjhXPeM5n5PHI3WyLTpdK96PDVm6c6dDtpUUj_ye9aWRtd5LzDAC4B8ARoJwdBqer05aCPCiVXqn0SqVXKg9K_eTu75-nwa9DX7j_YTa2rz9NX586MeO-5d9voEOABQ</recordid><startdate>20120607</startdate><enddate>20120607</enddate><creator>Park, Chung-Hwa</creator><creator>Jeong, Seung-Hee</creator><creator>Yim, Hyeon-Woo</creator><creator>Kim, Jin Dong</creator><creator>Bae, Si Hyun</creator><creator>Choi, Jong Young</creator><creator>Yoon, Seung Kew</creator><general>Baishideng Publishing Group Co., Limited</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20120607</creationdate><title>Family history influences the early onset of hepatocellular carcinoma</title><author>Park, Chung-Hwa ; Jeong, Seung-Hee ; Yim, Hyeon-Woo ; Kim, Jin Dong ; Bae, Si Hyun ; Choi, Jong Young ; Yoon, Seung Kew</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4031-f5bbb6dc8a6d20507340da72fa27890c58834fe905258ad21ca04381a3af37393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age of Onset</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alcoholism - complications</topic><topic>Brief</topic><topic>Carcinoma, Hepatocellular - diagnosis</topic><topic>Carcinoma, Hepatocellular - ethnology</topic><topic>Carcinoma, Hepatocellular - genetics</topic><topic>Family Health</topic><topic>Female</topic><topic>Genetic Predisposition to Disease</topic><topic>Hepatitis B, Chronic - complications</topic><topic>Hepatitis C, Chronic - complications</topic><topic>Humans</topic><topic>Korea</topic><topic>Liver Neoplasms - diagnosis</topic><topic>Liver Neoplasms - ethnology</topic><topic>Liver Neoplasms - genetics</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>丙型肝炎</topic><topic>乙型肝炎病毒</topic><topic>原发性肝癌</topic><topic>发病</topic><topic>家族史</topic><topic>早期诊断</topic><topic>病毒感染</topic><topic>肝细胞癌</topic><toplevel>online_resources</toplevel><creatorcontrib>Park, Chung-Hwa</creatorcontrib><creatorcontrib>Jeong, Seung-Hee</creatorcontrib><creatorcontrib>Yim, Hyeon-Woo</creatorcontrib><creatorcontrib>Kim, Jin Dong</creatorcontrib><creatorcontrib>Bae, Si Hyun</creatorcontrib><creatorcontrib>Choi, Jong Young</creatorcontrib><creatorcontrib>Yoon, Seung Kew</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>World journal of gastroenterology : WJG</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Park, Chung-Hwa</au><au>Jeong, Seung-Hee</au><au>Yim, Hyeon-Woo</au><au>Kim, Jin Dong</au><au>Bae, Si Hyun</au><au>Choi, Jong Young</au><au>Yoon, Seung Kew</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Family history influences the early onset of hepatocellular carcinoma</atitle><jtitle>World journal of gastroenterology : WJG</jtitle><addtitle>World Journal of Gastroenterology</addtitle><date>2012-06-07</date><risdate>2012</risdate><volume>18</volume><issue>21</issue><spage>2661</spage><epage>2667</epage><pages>2661-2667</pages><issn>1007-9327</issn><eissn>2219-2840</eissn><abstract>AIM： To evaluate the relationship between a positive family history of primary liver cancer and hepatocellular carcinoma （HCC） development in Korean HCC patients. METHODS： We studied a total of 2242 patients diagnosed with HCC between January 1990 and July 2008, whose family history of primary liver cancer was clearly described in the medical records.positive family history of HCC and 2077 （92.6%） did not. The male to female ratio was 3.6：1, and the major causes of HCC were chronic hepatitis B virus （HBV） infection in 75.1%, chronic hepatitis C virus infection in 13.2% and alcohol in 3.1%. The median ages at diag- nosis in the positiveand negative-history groups were 52 years （range： 29-79 years） and 57 years （range： 18-89 years）, respectively （P 〈 0.0001）. Furthermore, among 1713 HCC patients with HBV infection, the number of patients under 45 years of age out of 136 patients with positive family history was 26 （19.1%）, whereas those out of 1577 patients with negative family history was 197 （12.5%）, suggesting that a positive family history may be associated with earlier development of HCC in the Korean population （P = 0.0028）. CONCLUSION： More intensive surveillance maybe recommended to those with a positive family history of HCC for earlier diagnosis and proper management especially when HBV infection is present.</abstract><cop>United States</cop><pub>Baishideng Publishing Group Co., Limited</pub><pmid>22690075</pmid><doi>10.3748/wjg.v18.i21.2661</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Baishideng "World Journal of" online journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Adolescent Adult Age of Onset Aged Aged, 80 and over Alcoholism - complications Brief Carcinoma, Hepatocellular - diagnosis Carcinoma, Hepatocellular - ethnology Carcinoma, Hepatocellular - genetics Family Health Female Genetic Predisposition to Disease Hepatitis B, Chronic - complications Hepatitis C, Chronic - complications Humans Korea Liver Neoplasms - diagnosis Liver Neoplasms - ethnology Liver Neoplasms - genetics Male Middle Aged Retrospective Studies Risk Factors 丙型肝炎 乙型肝炎病毒 原发性肝癌 发病 家族史 早期诊断 病毒感染 肝细胞癌 |
| title | Family history influences the early onset of hepatocellular carcinoma |
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