p38 MAPK activation promotes denervated Schwann cell phenotype and functions as a negative regulator of Schwann cell differentiation and myelination

Physical damage to the peripheral nerves triggers Schwann cell injury response in the distal nerves in an event termed Wallerian degeneration: the Schwann cells degrade their myelin sheaths and dedifferentiate, reverting to a phenotype that supports axon regeneration and nerve repair. The molecular...

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Veröffentlicht in:	The Journal of neuroscience 2012-05, Vol.32 (21), p.7158-7168
Hauptverfasser:	Yang, David P, Kim, Jihyun, Syed, Neeraja, Tung, Young-John, Bhaskaran, Ambily, Mindos, Thomas, Mirsky, Rhona, Jessen, Kristjan R, Maurel, Patrice, Parkinson, David B, Kim, Haesun A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Differentiation - physiology Coculture Techniques Early Growth Response Protein 2 - biosynthesis Female Fibroblast Growth Factor 2 - pharmacology JNK Mitogen-Activated Protein Kinases - biosynthesis Mice Mice, Inbred C57BL Myelin Sheath - metabolism Nerve Fibers, Myelinated - metabolism Nerve Fibers, Myelinated - physiology Neuregulin-1 - pharmacology p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors p38 Mitogen-Activated Protein Kinases - physiology Peripheral Nerve Injuries - metabolism Peripheral Nerve Injuries - physiopathology Rats Schwann Cells - metabolism Schwann Cells - physiology Sciatic Nerve - metabolism Sciatic Nerve - physiopathology Wallerian Degeneration - metabolism Wallerian Degeneration - physiopathology
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