Neonatal lupus syndrome in a Nigerian child
Neonatal lupus is a rare syndrome resulting from passively transferred maternal autoantibodies during pregnancy. A male infant was delivered at term to a 29-year-old primiparous woman who was diagnosed of systemic lupus erythematosus 2 years earlier and had detectable levels of autoantibodies (antin...
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| Veröffentlicht in: | BMJ case reports 2012-05, Vol.2012 (may11 1), p.bcr0120125710-bcr0120125710 |
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| creator | Abiodun, Moses Adelowo, Olufemi |
| description | Neonatal lupus is a rare syndrome resulting from passively transferred maternal autoantibodies during pregnancy. A male infant was delivered at term to a 29-year-old primiparous woman who was diagnosed of systemic lupus erythematosus 2 years earlier and had detectable levels of autoantibodies (antinuclear antibody (ANA), anti-dsDNA, anti-Ro and anti-La/SSB) in second trimester. However, the pregnancy was otherwise uneventful. He presented at the age of 8 week with a widespread hypopigmented macular rash on the trunk and patchy alopecia involving the hair line and the occipito-parietal regions of 3 weeks duration, anaemia and symptomatic thrombocytopaenia. Serologic test for autoantibodies was positive for ANA and anti-La/SSB. Further evaluation was normal. He was managed conservatively with blood products and topical corticosteroids. Mother was also advised to avoid direct exposure to sunlight and fluorescent light. Haematological parameters gradually normalised over 2 months and the skin lesions resolved completely by the age of 6 months. |
| doi_str_mv | 10.1136/bcr.01.2012.5710 |
| format | Article |
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A male infant was delivered at term to a 29-year-old primiparous woman who was diagnosed of systemic lupus erythematosus 2 years earlier and had detectable levels of autoantibodies (antinuclear antibody (ANA), anti-dsDNA, anti-Ro and anti-La/SSB) in second trimester. However, the pregnancy was otherwise uneventful. He presented at the age of 8 week with a widespread hypopigmented macular rash on the trunk and patchy alopecia involving the hair line and the occipito-parietal regions of 3 weeks duration, anaemia and symptomatic thrombocytopaenia. Serologic test for autoantibodies was positive for ANA and anti-La/SSB. Further evaluation was normal. He was managed conservatively with blood products and topical corticosteroids. Mother was also advised to avoid direct exposure to sunlight and fluorescent light. 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A male infant was delivered at term to a 29-year-old primiparous woman who was diagnosed of systemic lupus erythematosus 2 years earlier and had detectable levels of autoantibodies (antinuclear antibody (ANA), anti-dsDNA, anti-Ro and anti-La/SSB) in second trimester. However, the pregnancy was otherwise uneventful. He presented at the age of 8 week with a widespread hypopigmented macular rash on the trunk and patchy alopecia involving the hair line and the occipito-parietal regions of 3 weeks duration, anaemia and symptomatic thrombocytopaenia. Serologic test for autoantibodies was positive for ANA and anti-La/SSB. Further evaluation was normal. He was managed conservatively with blood products and topical corticosteroids. Mother was also advised to avoid direct exposure to sunlight and fluorescent light. Haematological parameters gradually normalised over 2 months and the skin lesions resolved completely by the age of 6 months.</description><subject>12 Months</subject><subject>Administration, Topical</subject><subject>Adrenal Cortex Hormones - administration & dosage</subject><subject>Africa</subject><subject>Babies</subject><subject>Black</subject><subject>Blood</subject><subject>Blood Component Transfusion</subject><subject>Case studies</subject><subject>Diagnosis, Differential</subject><subject>Hematology</subject><subject>Humans</subject><subject>Immunoglobulins</subject><subject>Infant, Newborn</subject><subject>Leukemia</subject><subject>Lupus</subject><subject>Lupus Erythematosus, Systemic - congenital</subject><subject>Lupus Erythematosus, Systemic - diagnosis</subject><subject>Lupus Erythematosus, Systemic - drug therapy</subject><subject>Male</subject><subject>Nigeria</subject><subject>Rare Disease</subject><issn>1757-790X</issn><issn>1757-790X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqFkctLAzEQxoMotqy9e5IFL0Jpndm8di-CiC8o9dKDt5DsZtst-6hJV-h_79bWUr2YywTym2_yzUfIJcIYkYpbk7ox4DgCjMZcIpyQPkouRzKB99Oje48MvF9CdyiymNFz0osiATyW0CfDqW1qvdZlWLar1od-U2euqWxY1KEOp8XcukLXYbooyuyCnOW69HawrwGZPT3OHl5Gk7fn14f7ycgwiGHE0iQBaxIqODVRLDCzCbO5BrRC05yxXCaSU2645iaPmREm4RlaHcdSZxENyN1OdtWaymaprddOl2rlikq7jWp0oX6_1MVCzZtPRan4HhqQm72Aaz5a69eqKnxqy1LXtmm9QkAOieDIOvT6D7psWld37hTKmEZSQKcZENhRqWu8dzY_fAZBbbNQXRYKUG2zUNssuparYxOHhp_Nd8BwB5hq-b_cF69dkQk</recordid><startdate>20120511</startdate><enddate>20120511</enddate><creator>Abiodun, Moses</creator><creator>Adelowo, Olufemi</creator><general>BMJ Publishing Group LTD</general><general>BMJ Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20120511</creationdate><title>Neonatal lupus syndrome in a Nigerian child</title><author>Abiodun, Moses ; Adelowo, Olufemi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b4080-4c990eb93653b2861de94efa01e6a3f44f797535b5a5bf84b6b95d1ea887ad23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>12 Months</topic><topic>Administration, Topical</topic><topic>Adrenal Cortex Hormones - administration & dosage</topic><topic>Africa</topic><topic>Babies</topic><topic>Black</topic><topic>Blood</topic><topic>Blood Component Transfusion</topic><topic>Case studies</topic><topic>Diagnosis, Differential</topic><topic>Hematology</topic><topic>Humans</topic><topic>Immunoglobulins</topic><topic>Infant, Newborn</topic><topic>Leukemia</topic><topic>Lupus</topic><topic>Lupus Erythematosus, Systemic - congenital</topic><topic>Lupus Erythematosus, Systemic - diagnosis</topic><topic>Lupus Erythematosus, Systemic - drug therapy</topic><topic>Male</topic><topic>Nigeria</topic><topic>Rare Disease</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abiodun, Moses</creatorcontrib><creatorcontrib>Adelowo, Olufemi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMJ case reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abiodun, Moses</au><au>Adelowo, Olufemi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neonatal lupus syndrome in a Nigerian child</atitle><jtitle>BMJ case reports</jtitle><addtitle>BMJ Case Rep</addtitle><date>2012-05-11</date><risdate>2012</risdate><volume>2012</volume><issue>may11 1</issue><spage>bcr0120125710</spage><epage>bcr0120125710</epage><pages>bcr0120125710-bcr0120125710</pages><issn>1757-790X</issn><eissn>1757-790X</eissn><abstract>Neonatal lupus is a rare syndrome resulting from passively transferred maternal autoantibodies during pregnancy. A male infant was delivered at term to a 29-year-old primiparous woman who was diagnosed of systemic lupus erythematosus 2 years earlier and had detectable levels of autoantibodies (antinuclear antibody (ANA), anti-dsDNA, anti-Ro and anti-La/SSB) in second trimester. However, the pregnancy was otherwise uneventful. He presented at the age of 8 week with a widespread hypopigmented macular rash on the trunk and patchy alopecia involving the hair line and the occipito-parietal regions of 3 weeks duration, anaemia and symptomatic thrombocytopaenia. Serologic test for autoantibodies was positive for ANA and anti-La/SSB. Further evaluation was normal. He was managed conservatively with blood products and topical corticosteroids. Mother was also advised to avoid direct exposure to sunlight and fluorescent light. Haematological parameters gradually normalised over 2 months and the skin lesions resolved completely by the age of 6 months.</abstract><cop>England</cop><pub>BMJ Publishing Group LTD</pub><pmid>22605870</pmid><doi>10.1136/bcr.01.2012.5710</doi><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | 12 Months Administration, Topical Adrenal Cortex Hormones - administration & dosage Africa Babies Black Blood Blood Component Transfusion Case studies Diagnosis, Differential Hematology Humans Immunoglobulins Infant, Newborn Leukemia Lupus Lupus Erythematosus, Systemic - congenital Lupus Erythematosus, Systemic - diagnosis Lupus Erythematosus, Systemic - drug therapy Male Nigeria Rare Disease |
| title | Neonatal lupus syndrome in a Nigerian child |
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