A New Therapeutic Approach Using a Schizophyllan-based Drug Delivery System for Inflammatory Bowel Disease

Antisense technologies for the targeted inhibition of gene expression could provide an effective strategy for the suppression of inflammation. However, the effective use of antisense oligonucleotides (ODN) has been limited because of several problems. Therefore, a delivery system for antisense ODNs...

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Veröffentlicht in:	Molecular therapy 2012-06, Vol.20 (6), p.1234-1241
Hauptverfasser:	Takedatsu, Hidetoshi, Mitsuyama, Keiichi, Mochizuki, Shinichi, Kobayashi, Teppei, Sakurai, Kazuo, Takeda, Hiroshi, Fujiyama, Yoshihide, Koyama, Yoshikazu, Nishihira, Jun, Sata, Michio
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cells, Cultured Colitis - chemically induced Colitis - metabolism Colitis - therapy Cytokines - metabolism Dextran Sulfate - adverse effects Disease Models, Animal Drug Delivery Systems - methods Female Humans Inflammatory bowel disease Inflammatory Bowel Diseases - chemically induced Inflammatory Bowel Diseases - metabolism Inflammatory Bowel Diseases - therapy Intestinal Mucosa Lectins, C-Type - metabolism Macrophage Migration-Inhibitory Factors - chemistry Macrophage Migration-Inhibitory Factors - metabolism Macrophages - drug effects Macrophages - metabolism Mice Mice, Inbred C57BL Oligonucleotides, Antisense - administration & dosage Oligonucleotides, Antisense - chemistry Original Sizofiran - administration & dosage Sizofiran - chemistry
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