Recurrent network activity drives striatal synaptogenesis

Neurotransmitter release and activity are modulated in the striatum of mice to demonstrate that the balance of activity within the two antagonistic, inhibitory pathways co-mingled in this nucleus regulates excitatory innervation of the basal ganglia during development. Role of neural activity in dev...

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Veröffentlicht in:	Nature (London) 2012-05, Vol.485 (7400), p.646-650
Hauptverfasser:	Kozorovitskiy, Yevgenia, Saunders, Arpiar, Johnson, Caroline A., Lowell, Bradford B., Sabatini, Bernardo L.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/378/1457/1936 631/378/1697 631/378/2571/2577 631/378/2632/1323 Animals Artificial chromosomes Basal Ganglia - cytology Basal Ganglia - embryology Basal Ganglia - physiology Biological and medical sciences Brain Brain research Cerebral Cortex - cytology Cerebral Cortex - physiology Feedback, Physiological Female Fundamental and applied biological sciences. Psychology gamma-Aminobutyric Acid - metabolism Humanities and Social Sciences letter Male Mice Mice, Transgenic Models, Neurological multidisciplinary Neostriatum - cytology Neostriatum - embryology Neostriatum - physiology Neural Inhibition Neural Pathways - physiology Neural transmission Neurology Neurosciences Physiological aspects Science Science (multidisciplinary) Synapses Synapses - metabolism Thalamus - cytology Thalamus - physiology Vertebrates: nervous system and sense organs Vesicular Inhibitory Amino Acid Transport Proteins - deficiency Vesicular Inhibitory Amino Acid Transport Proteins - genetics Vesicular Inhibitory Amino Acid Transport Proteins - metabolism
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