Iron repletion relocalizes hephaestin to a proximal basolateral compartment in polarized MDCK and Caco2 cells

► Hephaestin localizes in the perinuclear space in non-polarized cells. ► Hephaestin localizes in the perinuclear space in iron deficient and polarized cells. ► Hephaestin with apical iron moves near to basolateral membrane of polarized cells. ► Peri-basolateral location of hephaestin is accessible...

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Veröffentlicht in:	Biochemical and biophysical research communications 2012-05, Vol.421 (3), p.449-455
Hauptverfasser:	Lee, Seung-Min, Attieh, Zouhair K., Son, Hee Sook, Chen, Huijun, Bacouri-Haidar, Mhenia, Vulpe, Chris D.
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Amino Acid Sequence ANEMIAS Animals Apo-transferrin Biotinylation Caco-2 Cells Cell Polarity CERULOPLASMIN COPPER Dogs Enterocytes EXTRACELLULAR SPACE Ferroportin HEME Hephaestin Holo-transferrin Humans INTESTINES Intestines - metabolism IRON Iron - metabolism IRON SULFATES Membrane Proteins - metabolism MICE Molecular Sequence Data Sodium-Potassium-Exchanging ATPase - metabolism TRANSFERRIN UPTAKE
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