Glyoxalase 1 increases anxiety by reducing GABAA receptor agonist methylglyoxal

Glyoxalase 1 (Glo1) expression has previously been associated with anxiety in mice; however, its role in anxiety is controversial, and the underlying mechanism is unknown. Here, we demonstrate that GLO1 increases anxiety by reducing levels of methylglyoxal (MG), a GABAA receptor agonist. Mice overex...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of clinical investigation 2012-06, Vol.122 (6), p.2306-2315
Hauptverfasser:	Distler, Margaret G, Plant, Leigh D, Sokoloff, Greta, Hawk, Andrew J, Aneas, Ivy, Wuenschell, Gerald E, Termini, John, Meredith, Stephen C, Nobrega, Marcelo A, Palmer, Abraham A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anxiety - drug therapy Anxiety - enzymology Anxiety - genetics Brain - enzymology Brain Chemistry - drug effects GABA-A Receptor Agonists - pharmacokinetics GABA-A Receptor Agonists - pharmacology Lactoylglutathione Lyase - genetics Lactoylglutathione Lyase - metabolism Male Mice Mice, Transgenic Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Pyruvaldehyde - pharmacokinetics Pyruvaldehyde - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!