Factors affecting mortality following myeloablative cord blood transplantation in adults: a pooled analysis of three international registries

A retrospective analysis was conducted to examine factors affecting early mortality after myeloablative, single-unit cord blood transplantation (CBT) for hematological malignancies in adolescents and adults. Data were collected from the three main CBT registries pooling 514 records of unrelated, single, unmanipulated, first myeloablative allogeneic CBTs conducted in North America or Europe from 1995 to 2005, with an HLA match ⩾4/6 loci, in patients aged 12–55. Overall 100-day, 180-day and 1-year survival (Kaplan–Meier method) were 56, 46 and 37%, respectively, with no significant heterogeneity across registries. Multivariate analysis showed cell dose