CCR5 Promoter Polymorphisms in a Kenyan Perinatal Human Immunodeficiency Virus Type 1 Cohort: Association with Increased 2-Year Maternal Mortality

The CCR5 chemokine receptor acts as a coreceptor with CD4 to permit infection by primary macrophage-tropic human immunodeficiency virus type 1 (HIV-1) strains. The CCR5Δ32 mutation, which is associated with resistance to infection in homozygous individuals and delayed disease progression in heterozy...

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Veröffentlicht in:	The Journal of infectious diseases 2001-07, Vol.184 (1), p.89-92
Hauptverfasser:	John, Grace C., Bird, Thomas, Overbaugh, Julie, Nduati, Ruth, Mbori-Ngacha, Dorothy, Rostron, Tim, Dong, Tao, Kostrikis, Leondios, Richardson, Barbra, Rowland-Jones, Sarah L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult AIDS Alleles Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Breast Feeding CCR5 protein Cohort Studies Concise Communications Disease progression Disease transmission Female Genetic mutation Genotype Genotypes Heterozygote HIV 1 HIV Infections - genetics HIV Infections - transmission HIV-1 - pathogenicity Homozygote Human immunodeficiency virus 1 Human viral diseases Humans Infant Infant, Newborn Infections Infectious Disease Transmission, Vertical Infectious diseases Kenya Male Maternal mortality rates Medical sciences Pharmacology. Drug treatments Polymorphism, Genetic Receptors, CCR5 - genetics Survival Rate Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Viral Load Viremia - genetics Women
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