IgG4-related inflammatory pseudotumor of the central nervous system responsive to mycophenolate mofetil
Abstract Orbital apex and skull base masses often present with neuro-ophthalmic signs and symptoms. Though the localization of these syndromes and visualization of the responsible lesion on imaging is typically straightforward, definitive diagnosis usually relies on biopsy. Immunohistochemistry is i...
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| Veröffentlicht in: | Journal of the neurological sciences 2012-07, Vol.318 (1), p.31-35 |
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| container_title | Journal of the neurological sciences |
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| creator | Moss, Heather E Mejico, Luis J de la Roza, Gustavo Coyne, Thomas M Galetta, Steven L Liu, Grant T |
| description | Abstract Orbital apex and skull base masses often present with neuro-ophthalmic signs and symptoms. Though the localization of these syndromes and visualization of the responsible lesion on imaging is typically straightforward, definitive diagnosis usually relies on biopsy. Immunohistochemistry is important for categorization and treatment planning. IgG4–related disease is emerging as a pathologically defined inflammatory process that can occur in multiple organ systems. We present two patients with extensive inflammatory mass lesions of the central nervous system with immunohistochemistry positive for IgG4 and negative for ALK-1 as examples of meningeal based IgG4-related inflammatory pseudotumors. In both patients, there was treatment response to mycophenolate mofetil. |
| doi_str_mv | 10.1016/j.jns.2012.04.010 |
| format | Article |
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Though the localization of these syndromes and visualization of the responsible lesion on imaging is typically straightforward, definitive diagnosis usually relies on biopsy. Immunohistochemistry is important for categorization and treatment planning. IgG4–related disease is emerging as a pathologically defined inflammatory process that can occur in multiple organ systems. We present two patients with extensive inflammatory mass lesions of the central nervous system with immunohistochemistry positive for IgG4 and negative for ALK-1 as examples of meningeal based IgG4-related inflammatory pseudotumors. In both patients, there was treatment response to mycophenolate mofetil.</description><identifier>ISSN: 0022-510X</identifier><identifier>EISSN: 1878-5883</identifier><identifier>DOI: 10.1016/j.jns.2012.04.010</identifier><identifier>PMID: 22546342</identifier><identifier>CODEN: JNSCAG</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Adult ; Biological and medical sciences ; Biopsy ; Central nervous system ; Central Nervous System - immunology ; Central Nervous System - pathology ; Female ; Granuloma, Plasma Cell - drug therapy ; Granuloma, Plasma Cell - pathology ; Human viral diseases ; Humans ; IgG4-related disease ; Immunoglobulin G ; Immunoglobulin G - biosynthesis ; Immunohistochemistry ; Immunosuppressive Agents - administration & dosage ; Infectious diseases ; Inflammation ; Inflammatory pseudotumor ; Intracranial mass ; Medical sciences ; Meningitis - drug therapy ; Meningitis - pathology ; Middle Aged ; Mycophenolate mofetil ; Mycophenolic Acid - administration & dosage ; Mycophenolic Acid - analogs & derivatives ; Neurology ; Optic neuropathy ; Pseudotumors ; Skull ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. 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Though the localization of these syndromes and visualization of the responsible lesion on imaging is typically straightforward, definitive diagnosis usually relies on biopsy. Immunohistochemistry is important for categorization and treatment planning. IgG4–related disease is emerging as a pathologically defined inflammatory process that can occur in multiple organ systems. We present two patients with extensive inflammatory mass lesions of the central nervous system with immunohistochemistry positive for IgG4 and negative for ALK-1 as examples of meningeal based IgG4-related inflammatory pseudotumors. In both patients, there was treatment response to mycophenolate mofetil.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Central nervous system</subject><subject>Central Nervous System - immunology</subject><subject>Central Nervous System - pathology</subject><subject>Female</subject><subject>Granuloma, Plasma Cell - drug therapy</subject><subject>Granuloma, Plasma Cell - pathology</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>IgG4-related disease</subject><subject>Immunoglobulin G</subject><subject>Immunoglobulin G - biosynthesis</subject><subject>Immunohistochemistry</subject><subject>Immunosuppressive Agents - administration & dosage</subject><subject>Infectious diseases</subject><subject>Inflammation</subject><subject>Inflammatory pseudotumor</subject><subject>Intracranial mass</subject><subject>Medical sciences</subject><subject>Meningitis - drug therapy</subject><subject>Meningitis - pathology</subject><subject>Middle Aged</subject><subject>Mycophenolate mofetil</subject><subject>Mycophenolic Acid - administration & dosage</subject><subject>Mycophenolic Acid - analogs & derivatives</subject><subject>Neurology</subject><subject>Optic neuropathy</subject><subject>Pseudotumors</subject><subject>Skull</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. Aids</subject><issn>0022-510X</issn><issn>1878-5883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkkuLFDEUhQtRnHb0B7iRbAQ31d48Kp1CGJBBx4EBFyq4C-nUre60VUmbpBrq35um2_GxEFdZ5Dsn5-bcqnpOYUmByte75c6nJQPKliCWQOFBtaBqpepGKf6wWgAwVjcUvl5UT1LaAYBUqn1cXTDWCMkFW1Sb282NqCMOJmNHnO8HM44mhziTfcKpC3kaQyShJ3mLxKLP0QzEYzyEKZE0p4wjiZj2wSd3QJIDGWcb9lv04ehJxtBjdsPT6lFvhoTPzudl9eX9u8_XH-q7jze312_vait5k2slexBtK3puURopWtWuGmHXrW3BwKpFaEzHpAVm5Xrd2R6BYwGwl52SFPlldXXy3U_rEbtzYL2PbjRx1sE4_eeNd1u9CQfNuZTQ8GLw6mwQw_cJU9ajSxaHwXgsI2sKXCiqqGj_A6WKC9FwVlB6Qm0MKUXs7xNROHJS73TpUh-71CB06bJoXvw-yr3iZ3kFeHkGTLJm6KPx1qVfnARYFbZwb04clo8_OIw6WYfeYuci2qy74P4Z4-ovtR2cd-XBbzhj2oUp-tKopjoVjf50XLrjzlEGQFeq4T8A8gDUVA</recordid><startdate>20120715</startdate><enddate>20120715</enddate><creator>Moss, Heather E</creator><creator>Mejico, Luis J</creator><creator>de la Roza, Gustavo</creator><creator>Coyne, Thomas M</creator><creator>Galetta, Steven L</creator><creator>Liu, Grant T</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope><scope>5PM</scope></search><sort><creationdate>20120715</creationdate><title>IgG4-related inflammatory pseudotumor of the central nervous system responsive to mycophenolate mofetil</title><author>Moss, Heather E ; Mejico, Luis J ; de la Roza, Gustavo ; Coyne, Thomas M ; Galetta, Steven L ; Liu, Grant T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c635t-86f04994f3ce6a64989754cb9c90a079e05ad26c02c6bbdcfe03e54cef6d861e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Central nervous system</topic><topic>Central Nervous System - immunology</topic><topic>Central Nervous System - pathology</topic><topic>Female</topic><topic>Granuloma, Plasma Cell - drug therapy</topic><topic>Granuloma, Plasma Cell - pathology</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>IgG4-related disease</topic><topic>Immunoglobulin G</topic><topic>Immunoglobulin G - biosynthesis</topic><topic>Immunohistochemistry</topic><topic>Immunosuppressive Agents - administration & dosage</topic><topic>Infectious diseases</topic><topic>Inflammation</topic><topic>Inflammatory pseudotumor</topic><topic>Intracranial mass</topic><topic>Medical sciences</topic><topic>Meningitis - drug therapy</topic><topic>Meningitis - pathology</topic><topic>Middle Aged</topic><topic>Mycophenolate mofetil</topic><topic>Mycophenolic Acid - administration & dosage</topic><topic>Mycophenolic Acid - analogs & derivatives</topic><topic>Neurology</topic><topic>Optic neuropathy</topic><topic>Pseudotumors</topic><topic>Skull</topic><topic>Viral diseases</topic><topic>Viral diseases of the lymphoid tissue and the blood. Aids</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moss, Heather E</creatorcontrib><creatorcontrib>Mejico, Luis J</creatorcontrib><creatorcontrib>de la Roza, Gustavo</creatorcontrib><creatorcontrib>Coyne, Thomas M</creatorcontrib><creatorcontrib>Galetta, Steven L</creatorcontrib><creatorcontrib>Liu, Grant T</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of the neurological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moss, Heather E</au><au>Mejico, Luis J</au><au>de la Roza, Gustavo</au><au>Coyne, Thomas M</au><au>Galetta, Steven L</au><au>Liu, Grant T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>IgG4-related inflammatory pseudotumor of the central nervous system responsive to mycophenolate mofetil</atitle><jtitle>Journal of the neurological sciences</jtitle><addtitle>J Neurol Sci</addtitle><date>2012-07-15</date><risdate>2012</risdate><volume>318</volume><issue>1</issue><spage>31</spage><epage>35</epage><pages>31-35</pages><issn>0022-510X</issn><eissn>1878-5883</eissn><coden>JNSCAG</coden><abstract>Abstract Orbital apex and skull base masses often present with neuro-ophthalmic signs and symptoms. Though the localization of these syndromes and visualization of the responsible lesion on imaging is typically straightforward, definitive diagnosis usually relies on biopsy. Immunohistochemistry is important for categorization and treatment planning. IgG4–related disease is emerging as a pathologically defined inflammatory process that can occur in multiple organ systems. We present two patients with extensive inflammatory mass lesions of the central nervous system with immunohistochemistry positive for IgG4 and negative for ALK-1 as examples of meningeal based IgG4-related inflammatory pseudotumors. In both patients, there was treatment response to mycophenolate mofetil.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>22546342</pmid><doi>10.1016/j.jns.2012.04.010</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Biological and medical sciences Biopsy Central nervous system Central Nervous System - immunology Central Nervous System - pathology Female Granuloma, Plasma Cell - drug therapy Granuloma, Plasma Cell - pathology Human viral diseases Humans IgG4-related disease Immunoglobulin G Immunoglobulin G - biosynthesis Immunohistochemistry Immunosuppressive Agents - administration & dosage Infectious diseases Inflammation Inflammatory pseudotumor Intracranial mass Medical sciences Meningitis - drug therapy Meningitis - pathology Middle Aged Mycophenolate mofetil Mycophenolic Acid - administration & dosage Mycophenolic Acid - analogs & derivatives Neurology Optic neuropathy Pseudotumors Skull Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids |
| title | IgG4-related inflammatory pseudotumor of the central nervous system responsive to mycophenolate mofetil |
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