Roles of Kruppel-associated Box (KRAB)-associated Co-repressor KAP1 Ser-473 Phosphorylation in DNA Damage Response

The Kruppel-associated box (KRAB)-associated co-repressor KAP1 is an essential nuclear co-repressor for the KRAB zinc finger protein superfamily of transcriptional factors. Ataxia telangiectasia mutated (ATM)-Chk2 and ATM- and Rad3-related (ATR)-Chk1 are two primary kinase signaling cascades activat...

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Veröffentlicht in:	The Journal of biological chemistry 2012-06, Vol.287 (23), p.18937-18952
Hauptverfasser:	Hu, Chen, Zhang, Shengping, Gao, Xuan, Gao, Xiaojing, Xu, Xiaohong, Lv, Ya, Zhang, Yan, Zhu, Zhenhong, Zhang, Changqing, Li, Qiao, Wong, Jiemin, Cui, Yongping, Zhang, Wen, Ma, Lin, Wang, Chuangui
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Apoptosis - physiology Ataxia Telangiectasia Mutated Proteins Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Checkpoint Kinase 1 Checkpoint Kinase 2 Chk2 Chromatin Assembly and Disassembly Co-repressor Transcription DNA Damage DNA Damage Response DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism E2F Transcription Factor E2F1 E2F1 Transcription Factor - genetics E2F1 Transcription Factor - metabolism HEK293 Cells HeLa Cells HP1 Humans KAP1 KRAB-ZNFs Phosphorylation - genetics Protein Kinases - genetics Protein Kinases - metabolism Protein Phosphorylation Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Repressor Proteins - genetics Repressor Proteins - metabolism Serine - genetics Serine - metabolism Signal Transduction Tripartite Motif-Containing Protein 28 Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism
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