C-terminal Acidic Cluster Is Involved in Ca2+-induced Regulation of Human Transient Receptor Potential Ankyrin 1 Channel

The transient receptor potential ankyrin 1 (TRPA1) channel is a Ca2+-permeable cation channel whose activation results from a complex synergy between distinct activation sites, one of which is especially important for determining its sensitivity to chemical, voltage and cold stimuli. From the cytopl...

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Veröffentlicht in:	The Journal of biological chemistry 2012-05, Vol.287 (22), p.18067-18077
Hauptverfasser:	Sura, Lucie, Zíma, Vlastimil, Marsakova, Lenka, Hynkova, Anna, Barvík, Ivan, Vlachova, Viktorie
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Ankyrin Receptor Subtype 1 Calcium - metabolism Calcium Channels - chemistry Calcium Channels - metabolism Calcium Channels - physiology Calcium Signaling Calcium-binding Domain Cell Line Gating Humans Ion Channels Molecular Dynamics Simulation Molecular Sequence Data Mutation Nerve Tissue Proteins - chemistry Nerve Tissue Proteins - metabolism Nerve Tissue Proteins - physiology Neurobiology Pain Sequence Homology, Amino Acid Transient Receptor Potential Transient Receptor Potential Channels - chemistry Transient Receptor Potential Channels - metabolism Transient Receptor Potential Channels - physiology TRP Channels TRPA1 TRPA1 Cation Channel
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