Molecular Recognition of Candida albicans (1→2)-β-Mannan Oligosaccharides by a Protective Monoclonal Antibody Reveals the Immunodominance of Internal Saccharide Residues

A self-consistent model of β-mannan oligosaccharides bound to a monoclonal antibody, C3.1, that protects mice against Candida albicans has been developed through chemical mapping, NMR spectroscopic, and computational studies. This antibody optimally binds di- and trisaccharide epitopes, whereas larg...

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Veröffentlicht in:	The Journal of biological chemistry 2012-05, Vol.287 (22), p.18078-18090
Hauptverfasser:	Johnson, Margaret A., Cartmell, Jonathan, Weisser, Nina E., Woods, Robert J., Bundle, David R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Antibodies, Monoclonal - immunology Candida Candida albicans - metabolism Carbohydrate Carbohydrate Sequence Computer Simulation Epitope Mapping Glycobiology and Extracellular Matrices Glycoconjugate Vaccines Homology Modeling Immunodominant Epitopes - chemistry Immunodominant Epitopes - immunology Mannans - chemistry Mannans - immunology Mannans - metabolism Models, Molecular Molecular Dynamics Simulation Molecular Sequence Data Nuclear Magnetic Resonance Nuclear Magnetic Resonance, Biomolecular STD-NMR Transferred NOE NMR Vaccine Development
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