Curcumin eliminates the inhibitory effect of advanced glycation end-products (AGEs) on gene expression of AGE receptor-1 in hepatic stellate cells in vitro

Diabetes is featured by hyperglycemia, which facilitates the formation of advanced glycation end-products (AGEs). AGEs are a causal factor in development of diabetic complications. AGE receptor-1 (AGE-R1) is responsible for detoxification and clearance of AGEs. Type 2 diabetes mellitus is commonly a...

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Veröffentlicht in:	Laboratory investigation 2012-06, Vol.92 (6), p.827-841
Hauptverfasser:	Lin, Jianguo, Tang, Youcai, Kang, Qiaohua, Chen, Anping
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/199 692/698/2741/288/2140 692/699/2743/137/773 Animals Biological and medical sciences Biotechnology Cell Proliferation - drug effects Cells, Cultured Curcuma longa Curcumin - pharmacology diabetes Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Extracellular Signal-Regulated MAP Kinases - biosynthesis Fundamental and applied biological sciences. Psychology gene expression Gene Expression - drug effects Glycation End Products, Advanced - pharmacology hepatic fibrosis hepatic stellate cell Hepatic Stellate Cells - drug effects Hepatic Stellate Cells - metabolism Hepatic Stellate Cells - pathology hyperglycemia Investigative techniques, diagnostic techniques (general aspects) Laboratory Medicine Male Medical sciences Medicine Medicine & Public Health Pathology PPAR gamma - biosynthesis Rats Rats, Sprague-Dawley Receptor for Advanced Glycation End Products Receptors, Immunologic - genetics Receptors, Immunologic - metabolism research-article RNA, Messenger - metabolism
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