Reagentless Oxidative Folding of Disulfide-Rich Peptides Catalyzed by an Intramolecular Diselenide

Building bridges: In cysteine‐rich peptides, diselenides can be used as a proxy for disulfide bridges as the energetic preference for SeSe bonds over mixed SeS bonds simplifies folding (see picture). An intramolecular diselenide bond efficiently catalyzes the oxidative folding of selenopeptide ana...

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Veröffentlicht in:	Angewandte Chemie International Edition 2012-06, Vol.51 (23), p.5580-5584
Hauptverfasser:	Steiner, Andrew M., Woycechowsky, Kenneth J., Olivera, Baldomero M., Bulaj, Grzegorz
Format:	Artikel
Sprache:	eng
Schlagworte:	Bridges (structures) Bridging Buildings Catalysis Conotoxins - chemistry Conotoxins - metabolism Construction Cysteine - chemistry Disulfides Disulfides - chemistry Folding Formations kinetics oxidation Oxidation-Reduction oxygen Peptides Peptides - chemistry Pictures Protein Folding selenium Selenium - chemistry
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