Global hypomethylation in hepatocellular carcinoma and its relationship to aflatoxin B1 exposure

AIM:To determine global DNA methylation in paired hepatocellular carcinoma(HCC) samples using several different assays and explore the correlations between hypomethylation and clinical parameters and biomarkers,including that of aflatoxin B 1 exposure.METHODS:Using the radio labeled methyl acceptanc...

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Veröffentlicht in:	World journal of hepatology 2012-05, Vol.4 (5), p.169-175
Hauptverfasser:	Zhang, Yu-Jing, Wu, Hui-Chen, Yazici, Hulya, Yu, Ming-Whei, Lee, Po-Huang, Santella, Regina M
Format:	Artikel
Sprache:	eng
Schlagworte:	acceptance Aflatoxin assay Brief carcinoma element-1 Epigenetics H]-methyl Hepatocellular Hypomethylation interspersed Long nucleotide Satellite
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