The YYRR box: a conserved dipyrimidine-dipurine sequence element in Drosophila and other eukaryotes
We have discovered a novel DNA sequence element in Drosophila which is based upon a CTGA tandem repeat. This element has been named the YYRR box to emphasize its dipyrimidine-dipurine nature which is predicted to have unusual structural features. Southern hybridization analysis of genomic DNA indica...
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| Veröffentlicht in: | Nucleic acids research 1988-04, Vol.16 (8), p.3375-3390 |
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| creator | CAVENER, D YUE FENG FOSTER, B KRASNEY, P MURTHA, M SCHONBAUM, C XIAO XIAO |
| description | We have discovered a novel DNA sequence element in Drosophila which is based upon a CTGA tandem repeat. This element has been named the YYRR box to emphasize its dipyrimidine-dipurine nature which is predicted to have unusual structural features. Southern hybridization analysis of genomic DNA indicates the presence of 25-30 copies of the YYRR box in each of three Drosophila species (melanogaster, pseudoobscura, and virilis) and conservation of genomic location within species. Similar analysis of human and rat DNA indicates the presence of YYRR related sequences in mammals as well. YYRR boxes have been localized to two genetic loci in Drosophila: Gld and a gene tentative identified as ted. These two genes exhibit correlated patterns of developmental expression and an identical mutant phenotype. Sequence analysis of the Gld YYRR box in three Drosophila species revealed a high degree of conservation despite its intronic location. |
| doi_str_mv | 10.1093/nar/16.8.3375 |
| format | Article |
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This element has been named the YYRR box to emphasize its dipyrimidine-dipurine nature which is predicted to have unusual structural features. Southern hybridization analysis of genomic DNA indicates the presence of 25-30 copies of the YYRR box in each of three Drosophila species (melanogaster, pseudoobscura, and virilis) and conservation of genomic location within species. Similar analysis of human and rat DNA indicates the presence of YYRR related sequences in mammals as well. YYRR boxes have been localized to two genetic loci in Drosophila: Gld and a gene tentative identified as ted. These two genes exhibit correlated patterns of developmental expression and an identical mutant phenotype. Sequence analysis of the Gld YYRR box in three Drosophila species revealed a high degree of conservation despite its intronic location.</description><identifier>ISSN: 0305-1048</identifier><identifier>EISSN: 1362-4962</identifier><identifier>DOI: 10.1093/nar/16.8.3375</identifier><identifier>PMID: 3375058</identifier><identifier>CODEN: NARHAD</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Animals ; Biological and medical sciences ; Drosophila ; Drosophila - genetics ; Drosophilidae ; Fundamental and applied biological sciences. Psychology ; Genes. Genome ; Humans ; Molecular and cellular biology ; Molecular genetics ; Rats - genetics ; Repetitive Sequences, Nucleic Acid ; Species Specificity</subject><ispartof>Nucleic acids research, 1988-04, Vol.16 (8), p.3375-3390</ispartof><rights>1988 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c402t-5c2776332bf4453d9f503ee02d57b31f8a6d6ab7319a3968072c43a1bde6d88f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC336500/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC336500/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7631937$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3375058$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CAVENER, D</creatorcontrib><creatorcontrib>YUE FENG</creatorcontrib><creatorcontrib>FOSTER, B</creatorcontrib><creatorcontrib>KRASNEY, P</creatorcontrib><creatorcontrib>MURTHA, M</creatorcontrib><creatorcontrib>SCHONBAUM, C</creatorcontrib><creatorcontrib>XIAO XIAO</creatorcontrib><title>The YYRR box: a conserved dipyrimidine-dipurine sequence element in Drosophila and other eukaryotes</title><title>Nucleic acids research</title><addtitle>Nucleic Acids Res</addtitle><description>We have discovered a novel DNA sequence element in Drosophila which is based upon a CTGA tandem repeat. This element has been named the YYRR box to emphasize its dipyrimidine-dipurine nature which is predicted to have unusual structural features. Southern hybridization analysis of genomic DNA indicates the presence of 25-30 copies of the YYRR box in each of three Drosophila species (melanogaster, pseudoobscura, and virilis) and conservation of genomic location within species. Similar analysis of human and rat DNA indicates the presence of YYRR related sequences in mammals as well. YYRR boxes have been localized to two genetic loci in Drosophila: Gld and a gene tentative identified as ted. These two genes exhibit correlated patterns of developmental expression and an identical mutant phenotype. Sequence analysis of the Gld YYRR box in three Drosophila species revealed a high degree of conservation despite its intronic location.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Drosophila</subject><subject>Drosophila - genetics</subject><subject>Drosophilidae</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genes. Genome</subject><subject>Humans</subject><subject>Molecular and cellular biology</subject><subject>Molecular genetics</subject><subject>Rats - genetics</subject><subject>Repetitive Sequences, Nucleic Acid</subject><subject>Species Specificity</subject><issn>0305-1048</issn><issn>1362-4962</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFrFDEUxoModVs9ehRyEG-zTfKSzIzgoVSrQkEo9dBTyCRv3OhssiYzxf73Zumy6MlTEr7fC9_3PkJecbbmrIfzaPM51-tuDdCqJ2TFQYtG9lo8JSsGTDWcye45OS3lB2NcciVPyMmeZapbEXe7QXp3d3NDh_T7HbXUpVgw36OnPuwectgGHyI29bHkeqEFfy0YHVKccItxpiHSDzmVtNuEyVIbPU3zBjPF5afND2nG8oI8G-1U8OXhPCPfrj7eXn5urr9--nJ5cd04ycTcKCfaVgOIYZRSge9HxQCRCa_aAfjYWe21HVrgvYVed6wVToLlg0ftu26EM_L-8d_dMmzRu-ou28nsaojqxCQbzL9KDBvzPd0bAK0Yq_NvD_M51ZBlNttQHE6TjZiWYtpOSM5B_hfkigsmha5g8wi6uqGScTya4czs2zO1PcO16cy-kcq__jvBkT7UVfU3B90WZ6cx2-hCOWJ1e7yHFv4Ai0mkPA</recordid><startdate>19880425</startdate><enddate>19880425</enddate><creator>CAVENER, D</creator><creator>YUE FENG</creator><creator>FOSTER, B</creator><creator>KRASNEY, P</creator><creator>MURTHA, M</creator><creator>SCHONBAUM, C</creator><creator>XIAO XIAO</creator><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19880425</creationdate><title>The YYRR box: a conserved dipyrimidine-dipurine sequence element in Drosophila and other eukaryotes</title><author>CAVENER, D ; YUE FENG ; FOSTER, B ; KRASNEY, P ; MURTHA, M ; SCHONBAUM, C ; XIAO XIAO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c402t-5c2776332bf4453d9f503ee02d57b31f8a6d6ab7319a3968072c43a1bde6d88f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Drosophila</topic><topic>Drosophila - genetics</topic><topic>Drosophilidae</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genes. Genome</topic><topic>Humans</topic><topic>Molecular and cellular biology</topic><topic>Molecular genetics</topic><topic>Rats - genetics</topic><topic>Repetitive Sequences, Nucleic Acid</topic><topic>Species Specificity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CAVENER, D</creatorcontrib><creatorcontrib>YUE FENG</creatorcontrib><creatorcontrib>FOSTER, B</creatorcontrib><creatorcontrib>KRASNEY, P</creatorcontrib><creatorcontrib>MURTHA, M</creatorcontrib><creatorcontrib>SCHONBAUM, C</creatorcontrib><creatorcontrib>XIAO XIAO</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nucleic acids research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CAVENER, D</au><au>YUE FENG</au><au>FOSTER, B</au><au>KRASNEY, P</au><au>MURTHA, M</au><au>SCHONBAUM, C</au><au>XIAO XIAO</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The YYRR box: a conserved dipyrimidine-dipurine sequence element in Drosophila and other eukaryotes</atitle><jtitle>Nucleic acids research</jtitle><addtitle>Nucleic Acids Res</addtitle><date>1988-04-25</date><risdate>1988</risdate><volume>16</volume><issue>8</issue><spage>3375</spage><epage>3390</epage><pages>3375-3390</pages><issn>0305-1048</issn><eissn>1362-4962</eissn><coden>NARHAD</coden><abstract>We have discovered a novel DNA sequence element in Drosophila which is based upon a CTGA tandem repeat. This element has been named the YYRR box to emphasize its dipyrimidine-dipurine nature which is predicted to have unusual structural features. Southern hybridization analysis of genomic DNA indicates the presence of 25-30 copies of the YYRR box in each of three Drosophila species (melanogaster, pseudoobscura, and virilis) and conservation of genomic location within species. Similar analysis of human and rat DNA indicates the presence of YYRR related sequences in mammals as well. YYRR boxes have been localized to two genetic loci in Drosophila: Gld and a gene tentative identified as ted. These two genes exhibit correlated patterns of developmental expression and an identical mutant phenotype. Sequence analysis of the Gld YYRR box in three Drosophila species revealed a high degree of conservation despite its intronic location.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>3375058</pmid><doi>10.1093/nar/16.8.3375</doi><tpages>16</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Nucleic acids research, 1988-04, Vol.16 (8), p.3375-3390 |
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| language | eng |
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| source | Oxford University Press Journals Digital Archive legacy; MEDLINE; PubMed Central |
| subjects | Animals Biological and medical sciences Drosophila Drosophila - genetics Drosophilidae Fundamental and applied biological sciences. Psychology Genes. Genome Humans Molecular and cellular biology Molecular genetics Rats - genetics Repetitive Sequences, Nucleic Acid Species Specificity |
| title | The YYRR box: a conserved dipyrimidine-dipurine sequence element in Drosophila and other eukaryotes |
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