Breaking the HAC Barrier: Histone H3K9 acetyl/methyl balance regulates CENP-A assembly

The kinetochore is responsible for accurate chromosome segregation. However, the mechanism by which kinetochores assemble and are maintained remains unclear. Here we report that de novo CENP‐A assembly and kinetochore formation on human centromeric alphoid DNA arrays is regulated by a histone H3K9 a...

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Veröffentlicht in:	The EMBO journal 2012-05, Vol.31 (10), p.2391-2402
Hauptverfasser:	Ohzeki, Jun-ichirou, Bergmann, Jan H, Kouprina, Natalay, Noskov, Vladimir N, Nakano, Megumi, Kimura, Hiroshi, Earnshaw, William C, Larionov, Vladimir, Masumoto, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Autoantigens - metabolism Cell cycle CENP-A Centromere Protein A centromeres Chromosomal Proteins, Non-Histone - metabolism Chromosomes Deoxyribonucleic acid DNA DNA - metabolism EMBO06 EMBO09 epigenetic regulation Epigenetics heterochromatin Histones - metabolism Humans Kinetochores - metabolism Methylation Molecular biology Protein Multimerization Protein Processing, Post-Translational Proteins
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