Concomitant inactivation of Rb and E2f8 in hematopoietic stem cells synergizes to induce severe anemia

The retinoblastoma (Rb) tumor suppressor plays important roles in regulating hematopoiesis, particularly erythropoiesis. In an effort to understand whether Rb function can be mediated by E2F transcription factors in a BM-derived hematopoietic system in mice, we uncovered a functional synergy between...

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