An insertional mutagenesis screen identifies genes that cooperate with Mll-AF9 in a murine leukemogenesis model

Patients with a t(9;11) translocation (MLL-AF9) develop acute myeloid leukemia (AML), and while in mice the expression of this fusion oncogene also results in the development of myeloid leukemia, it is with long latency. To identify mutations that cooperate with Mll-AF9, we infected neonatal wild-ty...

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Veröffentlicht in:	Blood 2012-05, Vol.119 (19), p.4512-4523
Hauptverfasser:	Bergerson, Rachel J., Collier, Lara S., Sarver, Aaron L., Been, Raha A., Lugthart, Sanne, Diers, Miechaleen D., Zuber, Johannes, Rappaport, Amy R., Nixon, Molly J., Silverstein, Kevin A.T., Fan, Danhua, Lamblin, Anne-Francoise J., Wolff, Linda, Kersey, John H., Delwel, Ruud, Lowe, Scott W., O'Sullivan, M. Gerard, Kogan, Scott C., Adams, David J., Largaespada, David A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Biological and medical sciences Cell Transformation, Neoplastic - genetics Cells, Cultured Disease Models, Animal DNA Mutational Analysis - methods Gene Regulatory Networks - genetics HEK293 Cells Hematologic and hematopoietic diseases Humans Leukemia - genetics Leukemia - pathology Medical sciences Mice Mice, Inbred C57BL Murine leukemia virus Mutagenesis, Insertional - physiology Myeloid Neoplasia Myeloid-Lymphoid Leukemia Protein - genetics Myeloid-Lymphoid Leukemia Protein - physiology Oncogene Proteins, Fusion - genetics Oncogene Proteins, Fusion - physiology U937 Cells
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